4244 papers
This study systematically demonstrates that NSD2 is a pan-cancer biomarker with significant diagnostic and prognostic value, characterized by its overexpression in advanced tumors, association with poor survival and immune evasion, and potential as a therapeutic target for agents like H-7 and thapsigargin.
This study demonstrates that a reciprocal loop between the claustrum and the anterior cingulate cortex times cortical UP-to-DOWN state transitions through transient population synchrony, a mechanism essential for efficient cue-driven flexible behavior in mice.
Researchers isolated and characterized a highly thermostable and alkaline protease from *Bacillus licheniformis* MT_1, a bacterium found in Tuwa Hot Spring, Gujarat, which demonstrates optimal activity at pH 9.0 and 80°C, stability in harsh industrial conditions, and significant potential for detergent applications.
This paper proposes the Signed Error by Timing Asymmetry (SETA) model, which demonstrates how chandelier cells encode the sign of prediction errors by temporally gating layer 2/3 neuron firing to differentially trigger synaptic potentiation or depression in layer 5 targets, a mechanism validated through computational modeling and in vivo recordings in mouse visual cortex.
A study of a transport corridor in eastern Bhutan reveals that while overall plant species richness remains unchanged across elevation, invasive species dominate at lower elevations while native species richness significantly increases at higher elevations, indicating that road development and trade strongly alter community composition by suppressing native flora in lowland areas.
This study demonstrates that the gut commensal bacterium *Lachnospira eligens* alleviates ulcerative colitis in mice by producing the metabolite isodeoxycholic acid (isoDCA), which strengthens the intestinal barrier and suppresses inflammation through the inhibition of the STAT3/NF-κB signaling pathway.
This study demonstrates that while value representations in the anterior cingulate cortex and orbitofrontal cortex both emerge rapidly during learning, they utilize distinct coding strategies, with the anterior cingulate cortex employing a generalized format across training histories and the orbitofrontal cortex utilizing context-dependent codes.
This study reveals that senescent mesenchymal stem cells promote the migration and invasion of SMAD4-deficient colorectal cancer cells by secreting TGF-β to activate the non-classical PI3K/AKT pathway, thereby inducing epithelial-mesenchymal transition (EMT) that can be effectively reversed by the TGF-β receptor inhibitor LY-2109761.
DockTData is a newly released, openly licensed dataset that integrates 24,719 experimentally determined protein-ligand structures from the PDB with standardized bioactivity measurements from BindingDB and ChEMBL, providing a larger and reproducible resource for training machine learning models in structure-based drug discovery.
This study identifies elevated ERCC8 mRNA expression as a significant biomarker associated with high-risk myelodysplastic neoplasms and progression to acute myeloid leukemia, highlighting the critical role of aberrant DNA repair signaling in disease pathogenesis.