4244 papers
OmicFormer is a novel Transformer-based architecture that embeds statistical priors to capture complex biological dependencies, significantly outperforming existing methods in accuracy and generalizability across diverse disease prediction tasks and omics datasets.
This paper introduces a unified framework for modeling and controlling Boolean biological networks by integrating temporal, structural, and hybrid control mechanisms to manipulate attractors and state trajectories, thereby enabling the rational engineering of complex biological processes like cell differentiation.
This study presents XSingletO, a systemically delivered nanovesicle platform that utilizes X-ray irradiation to generate localized singlet oxygen within the brain, thereby activating endogenous neural stem cells via a PPARγ-dependent mechanism to drive neuronal regeneration, circuit repair, and functional recovery in traumatic brain injury models.
This paper introduces BMIM II, a biophysical framework modeling cognitive transduction as a Hopf bifurcation-driven phase transition in coupled Stuart-Landau oscillators, where multiplicative neural gains and thermodynamic noise determine the emergence of integrated thought and the etiology of cognitive disorders, validated through a real-time computational prototype and proposed clinical measurement protocols.
This paper analyzes the analytical and finite-population dynamics of defector-responsive strategy switching in the Prisoner's Dilemma, deriving exact cost constraints for its viability and demonstrating that while constant switching rapidly establishes retaliation at the expense of unconditional cooperators, responsive switching offers a superior tradeoff by preserving cooperation after rescuing it from defectors.
This study reports the first systematic screening of L-asparaginase production by *Pseudomonas reptilivora* ATCC 13626, identifying low agitation and asparagine supplementation as key factors for high enzyme yield while simultaneously discovering an inducible ureolytic capacity that challenges the species' classical classification.
This study utilizes triple transgenic mice to characterize the distinct distribution, molecular phenotypes, and differential odor-evoked activation patterns of Emx1-derived pallial and Otp-derived telencephalic-opto-hypothalamic glutamatergic neurons within the adult amygdala, revealing how their embryonic origins contribute to functional and sex-specific processing of olfactory cues.
This study of 5,851 healthy young adults reveals that a lifetime of perceived thermal stress has persistent, cumulative effects on brain structure, psychological well-being, and lifestyle behaviors, suggesting that subjective thermal discomfort is a critical factor in evaluating thermal-related neurological alterations.
This paper introduces circular tandem repeat proteins (cTRPs) as programmable, modular reference standards with defined nanoscale geometry and protein-like environments, enabling the rigorous benchmarking of sub-10 nm fluorescence microscopy performance in both purified and cellular contexts.
This study analyzes codon usage and CpG/UpA motif ordering in canine astrovirus genomes, revealing hierarchical evolutionary patterns where the rapidly evolving central capsid region of ORF2 exhibits the strongest depletion of these motifs and the closest alignment with host dog coding preferences, suggesting potential host-driven constraints on viral RNA evolution.