🧬 Category

q-bio

4244 papers

🧬 biology

Propagation electrodynamics and differential conduction of action potentials in geometrically branched squid giant axons

This study introduces a coupled Maxwell-electromagnetic cable framework that integrates magnetic induction, Lorentz forces, and quantum corrections to demonstrate how these neglected electrodynamics significantly alter action potential propagation, velocity scaling, and bifurcation transmission fidelity in branched squid giant axons compared to classical quasi-static models.

Xi Liu, Wenxi Fang, Ken Perlin2026-08-04
🧬 biology

Characterization, Identification, and Optimization of Amylase-producing Bacterial Isolates From Sewage Water and Soil Recieving Kitchen

This study characterizes and identifies amylase-producing bacterial isolates from sewage water and kitchen waste-enriched soil as belonging to the genera *Bacillus*, *Yersinia*, and *Providencia*, determining their optimal growth conditions and recommending these waste sources as viable reservoirs for industrial amylase production.

SHUMATE KEBEDE HIRPA, Melkam Dessalegn Liben, Abdulsebur Awol2026-08-04
🧬 biology

The anti-biofilm effects of terrein against Pseudomonas aeruginosa biofilms vary between strains

This study reveals that terrein exhibits significant strain-dependent variability in its anti-biofilm effects against *Pseudomonas aeruginosa*, acting as either an inhibitor or an inducer of biofilm formation depending on the specific strain's quorum sensing and c-di-GMP signaling pathways, with its efficacy being most pronounced during early biofilm development.

Yasuhiko Irie, Ella Alsö2026-08-04
🧬 biology

Separating drug main effects from molecular personalization in cancer drug-sensitivity prediction: a harmonized GDSC∪CTRP and CCLE benchmark with permutation-controlled biomarker discovery

By harmonizing GDSC, CTRP, and CCLE data with rigorous permutation-controlled benchmarks, this study demonstrates that most apparent predictive skill in cancer drug sensitivity stems from broad tissue-specific drug effects rather than genuine molecular personalization, while identifying a small but biologically validated set of personalized biomarkers through a novel two-stage significance protocol.

Yue Hao2026-08-04
🧬 biology

Axl inhibition on dendritic cells enhances STING anticancer therapy through type I interferon signaling

This study demonstrates that inhibiting the receptor tyrosine kinase Axl specifically in dendritic cells enhances anti-tumor immunity and STING agonist efficacy by relieving a negative checkpoint on type I interferon signaling, thereby boosting CD8⁺ T cell priming and tumor control.

Isaac Gonzalez, Eslam Elghonaimy, Qiongwen Zhang, Isaac Montgomery, Peter Leung, Arely Rodriguez, Sebastian Diegeler, Ka (…)2026-08-04
🧬 biology

Reconstituting Placenta–Embryo Crosstalk in a Microfluidic Chip for Human‑Relevant Developmental Toxicity Studies

This study presents a human-relevant microfluidic co-culture platform integrating a placental barrier model with hiPSC-derived embryoid bodies to dynamically recapitulate placenta-embryo crosstalk, thereby enabling more accurate mechanistic assessment of developmental toxicity by demonstrating how placental transport and metabolism modulate the effects of teratogens.

Tina Buerki-Thurnherr, Manon Murdeu, Isabel Wegner, Xialein Lin, Jacob Folz, Paula Navascués, Andreas Hierlemann, Julia (…)2026-08-04
🧬 biology

CircRNA-Mediated Reprogramming of Adipose-Derived Stem Cells to iPSCs for Efficient Derivation of Functional Mesenchymal Stem Cells

This study presents a safe, non-integrating, and cost-effective strategy that utilizes lipid nanoparticle-delivered circular RNAs to reprogram human adipose-derived stem cells into integration-free iPSCs, which are then efficiently differentiated into functional, rejuvenated mesenchymal stem cells with enhanced extracellular matrix properties for regenerative medicine applications.

Qiushi Liu, Yao Fu, E Xiao, Gong Xi2026-08-04