4244 papers
This study demonstrates that mesenchymal stem cell-derived apoptotic vesicles (MSC-ApoVs) alleviate acetaminophen-induced acute liver failure by delivering miR-378a-5p to inhibit NLRC5, thereby blocking hepatocyte PANoptosis and the assembly of the RIPK3-ASC-Caspase-8 PANoptosome complex.
This study utilizes graph theory to reveal that expert college soccer players exhibit distinct small-world brain gray matter network properties and more widespread hub distributions across cortical, subcortical, and cerebellar regions compared to novices, suggesting that network analysis better captures the covariance of gray matter volume associated with skill level.
This study analyzed amniotic fluid microbiota from pregnant women and found that while overall microbial diversity did not differ between fetuses with complex congenital heart disease and normal controls, the former group exhibited a significantly elevated abundance of specific microbial taxa associated with diabetes, inflammatory bowel disease, and periodontal disease.
This study reveals that the m6A demethylase ALKBH5 upregulates circARHGEF12, which acts as a competing endogenous RNA to sponge miR-130b-5p and activate LATS2 signaling, thereby suppressing gastric cancer progression and cisplatin resistance.
This study utilizes whole-genome resequencing in Norwegian-Swedish Coldblooded Trotters to demonstrate that dynamic laryngeal collapse is a polygenic trait driven by coordinated genomic differentiation across multiple loci involved in neuromotor, musculoskeletal, and craniofacial pathways, rather than by a single major-effect variant.
Naringin ameliorates Alzheimer's disease-like cognitive impairment and pathology in both cellular and transgenic mouse models by coordinately activating the Nrf2-mediated antioxidant defense and suppressing NF-κB-dependent neuroinflammation.
This paper documents *Hovenia acerba* as a distinct taxon newly recorded in the Western Himalaya of Jammu and Kashmir, providing a detailed morphological re-evaluation to differentiate it from *H. dulcis*, along with updated distributional data, an identification key, and an assessment of its IUCN conservation status.
This study demonstrates that elevated MUC16 expression in ovarian cancer omental metastases predicts poor clinical prognosis by correlating with reduced mature tertiary lymphoid structures and decreased CD3⁺ T cell infiltration, thereby reshaping an immunosuppressive tumor microenvironment.
This study demonstrates that apramycin formulated with various Dextran-based Single-Chain Polymeric Nanoparticles (DXT-SCPN) exhibits comparable in vitro antimicrobial activity against *Acinetobacter baumannii* clinical isolates to the free drug, with a slight, non-significant trend toward enhanced efficacy in specific formulations.
This study demonstrates that soil texture fundamentally mediates microbial responses to moisture stress by shaping distinct bacterial and fungal community assembly, network organization, and functional profiles, with bacterial communities showing stronger deterministic responses to drought than fungal communities.