4244 papers
This study reveals that patients with HBV-related cirrhosis exhibit a selective functional disconnection between the thalamus and striatum, which serves as an early neural signature of the disease despite the preservation of global subcortical network topology and the absence of overt cognitive impairment.
This study utilized dynamic transcriptomic profiling of peripheral blood mononuclear cells across four superovulation stages in dairy cows to identify key regulatory genes and molecular pathways, providing potential targets for improving superovulation efficiency and selection tools in multiple ovulation and embryo transfer (MOET) procedures.
This study utilizes single-cell RNA sequencing to characterize the immunosuppressive tumor microenvironment of testicular diffuse large B-cell lymphoma, revealing key mechanisms including T cell exhaustion, M2 macrophage polarization, Sertoli cell dysfunction, and the MIF-CD74 axis, while identifying MRC1 as a potential prognostic biomarker.
This study reports the synthesis and characterization of novel N,S,O-substituted 1,4-naphthoquinone derivatives, identifying compounds 4 and 13 as potent inducers of apoptosis in triple-negative breast cancer cells (MDA-MB-231) through combined experimental assays and computational molecular docking and dynamics simulations targeting the MCL-1 protein.
This study employs an integrated computational approach combining machine learning, molecular docking, and molecular dynamics simulations to design and validate novel non-toxic peptide inhibitors derived from α-bungarotoxin, identifying the P40 candidate as a promising therapeutic agent targeting the Rabies virus glycoprotein.
This study demonstrates that pre-cultured probiotic strains of *Bacillus amyloliquefaciens* and *Bacillus velezensis* effectively inhibit the growth of multidrug-resistant, beta-lactamase-producing Gram-negative pathogens isolated from hospital sink drains, offering a sustainable biocontrol alternative to chemical disinfection.
This study utilizes multimodal MRI fusion and machine learning to demonstrate that methamphetamine-predominant use is associated with distributed multiscale brain network alterations, while methadone maintenance induces partial, network-specific reorganization rather than a full return to healthy control patterns.
This study reports the first identification and genomic characterization of a carbapenem- and colistin-resistant *Enterobacter chengduensis* isolate carrying the *bla*NDM-1 gene in Northeast China, highlighting the emergence of multidrug-resistant strains with significant virulence and resistance factors.
This study documents the mating behavior of the apterous cricket *Unacla meridionalis*, revealing a prolonged two-hour copulation involving multiple spermatophore transfers and a unique post-copulatory pattern where females consume the spermatophores, suggesting a post-nuptial gift that contrasts with typical male consumption in related species.
This study demonstrates that proinflammatory cytokines in severe malaria patient sera induce endothelial cell dysfunction by coordinately disrupting the actin cytoskeleton and promoting mitochondrial fragmentation, thereby elucidating a key mechanism in malaria pathogenesis.