4245 papers
This study establishes bleomycin as a superior inducer of senescence in RAW 264.7 macrophages compared to lipopolysaccharide (LPS), demonstrating that bleomycin reliably triggers proliferative arrest and senescence markers without the confounding acute inflammatory activation characteristic of LPS treatment.
This study utilizes Detrended Fluctuation Analysis to demonstrate a strong correspondence between the fractal scaling properties of musical features (Pitch, Loudness, and Rhythm) and the distinct, scale-dependent neural responses observed in EEG signals, where calming music enhances long-range temporal correlations in slow brain waves while stimulating music promotes faster, less persistent activity in higher frequency bands.
This study demonstrates that human-specific RNA enrichment kits effectively deplete ribosomal RNA and significantly improve genome alignment efficiency in African savanna elephant whole blood samples, thereby establishing an optimized workflow for downstream transcriptomic analysis of immune responses in this non-model species.
This study reports the first detection and comprehensive characterization of a highly divergent Porcine Parvovirus 6 variant (NGRA4) in Nigeria, revealing its ancestral phylogenetic position, unique capsid structural features, and evidence of immune-driven evolution that underscores the need for enhanced surveillance of PPV6 in African swine populations.
This study demonstrates that the LiteVax adjuvant enhances influenza vaccine immunogenicity in older adults by inducing a transient, monocyte-driven interferon response that accelerates early IgG3 production and improves T-cell memory differentiation, thereby mitigating age-related immune decline.
This study reveals that seasonal changes and habitat types (water vs. sediment) jointly drive distinct shifts in the composition, interaction networks, and functional potential of microbial communities in urban rivers of Changzhou, with summer favoring nutrient cycling genes and winter emphasizing environmental adaptation.
This study demonstrates that PGK1 expression varies significantly across breast cancer molecular subtypes and serves as an independent predictor of shorter overall survival in the TCGA-BRCA cohort after adjusting for age, stage, and subtype.
This study demonstrates that while acute heat stress assays can predict coral thermotolerance, the real-world bleaching performance of nursery-propagated corals during the 2024 mass bleaching event is critically dependent on environmental context and species identity rather than microbial associations.
This study identifies a novel spinal trigeminal nucleus-to-hippocampus dopaminergic circuit that modulates malocclusion-induced TMD-related depression through a DRD2/NF-κB/LEPR signaling axis, offering new mechanistic insights and potential therapeutic targets for TMD-associated neuropsychiatric comorbidities.
This study analyzes nearly 47 hours of music from eight psilocybin therapy playlists using machine learning and finds that, despite the theoretical requirement for music to align with the onset–peak–return model of the psychedelic experience, current curatorial practices lack consistent acoustic and affective structure across these phases.