4247 papers
This study identifies a novel spinal trigeminal nucleus-to-hippocampus dopaminergic circuit that modulates malocclusion-induced TMD-related depression through a DRD2/NF-κB/LEPR signaling axis, offering new mechanistic insights and potential therapeutic targets for TMD-associated neuropsychiatric comorbidities.
This study analyzes nearly 47 hours of music from eight psilocybin therapy playlists using machine learning and finds that, despite the theoretical requirement for music to align with the onset–peak–return model of the psychedelic experience, current curatorial practices lack consistent acoustic and affective structure across these phases.
This pilot study demonstrates that broadband time domain diffuse optical spectroscopy, when combined with ultrasound, can noninvasively detect sex-related differences in superficial muscle and adipose tissue composition in healthy adults, while highlighting the critical need to account for subcutaneous adipose tissue thickness when interpreting depth-dependent optical measurements.
This exploratory study of young Japanese individuals reveals that one-year changes in trunk muscle echo intensity are negatively associated with plant protein and carbohydrate intake in males, but with HDL-cholesterol levels in females, highlighting sex-specific links between muscle quality and lifestyle factors.
This study demonstrates that while female CD1 mice exhibit greater peripheral metabolic protection against diet-induced obesity compared to males, both sexes experience similar central hypothalamic oxidative stress, highlighting the model's value in capturing human genetic diversity and sex-specific metabolic responses.
This study analyzes 40 high-quality *Pseudomonas fluorescens* genomes to reveal an exceptionally open pan-genome structure where strain-specific accessory genes drive diverse plant growth-promoting traits and biosynthetic capabilities, highlighting the species' genomic plasticity as a key factor in its ecological adaptability and potential for sustainable agriculture.
This study demonstrates that optimizing the balance between glucose and casamino acids in a semi-defined medium, while avoiding soybean oil, significantly enhances azomycin production by *Streptomyces eurocidicus*, achieving a final titer of 69.18 mg/L in a 3L bioreactor.
This study analyzes DNA methylation patterns in 62 pancreatic ductal adenocarcinoma patient-derived organoids to identify four distinct methylation-based clusters that reveal tumor heterogeneity and biological processes beyond existing transcriptomic subtypes, potentially guiding future treatment strategies.
This study elucidates the molecular mechanism of programmed B chromosome elimination in *Aegilops speltoides* roots, revealing that the overexpression of B-encoded cohesin (SYN2-B) and centromeric histone (CENH3-B) genes, potentially regulated by ethylene signaling, disrupts normal chromosome segregation to drive selective chromosome loss.
This study integrates cis-eQTL Mendelian randomization and colocalization analyses to prioritize *MAPK3* as a protective candidate and *UQCC1* as a risk-increasing candidate for osteoarthritis, while highlighting the need for further experimental validation to confirm causal mechanisms and distinguish signals from the adjacent *GDF5* locus.