4251 papers
This study demonstrates that optimizing the balance between glucose and casamino acids in a semi-defined medium, while avoiding soybean oil, significantly enhances azomycin production by *Streptomyces eurocidicus*, achieving a final titer of 69.18 mg/L in a 3L bioreactor.
This study analyzes DNA methylation patterns in 62 pancreatic ductal adenocarcinoma patient-derived organoids to identify four distinct methylation-based clusters that reveal tumor heterogeneity and biological processes beyond existing transcriptomic subtypes, potentially guiding future treatment strategies.
This study elucidates the molecular mechanism of programmed B chromosome elimination in *Aegilops speltoides* roots, revealing that the overexpression of B-encoded cohesin (SYN2-B) and centromeric histone (CENH3-B) genes, potentially regulated by ethylene signaling, disrupts normal chromosome segregation to drive selective chromosome loss.
This study integrates cis-eQTL Mendelian randomization and colocalization analyses to prioritize *MAPK3* as a protective candidate and *UQCC1* as a risk-increasing candidate for osteoarthritis, while highlighting the need for further experimental validation to confirm causal mechanisms and distinguish signals from the adjacent *GDF5* locus.
This study characterizes the Cooum River in Chennai as a significant environmental reservoir for multidrug-resistant and hypervirulent *Klebsiella pneumoniae*, highlighting the critical public health risks posed by the high prevalence of colistin-resistant strains carrying key virulence genes in urban aquatic ecosystems.
By integrating single-cell and spatial transcriptomics with computational modeling, this study defines a C3-centered multicellular ecology in colorectal liver metastasis characterized by a specific malignant state and stromal-vascular interactions that drive poor prognosis and reveal a MAPK-linked network vulnerability potentially targetable by PD-0325901.
This study demonstrates that the malignant differentiation state of B-cell lymphomas, rather than histological subtype, causally dictates the spatial organization and immune composition of the tumor microenvironment, revealing a shared developmental continuum where dark zone states drive immune depletion and post-germinal center states promote immunosuppression.
This study identifies DIP2C as an independent favorable prognostic biomarker and tumor suppressor in kidney renal clear cell carcinoma (KIRC) through comprehensive pan-cancer bioinformatic analyses and in vitro functional validation demonstrating that its downregulation correlates with poor survival and enhanced cell migration.
This study demonstrates that actin polymerization is essential for the active, temperature-sensitive internalization of diverse tattoo pigments by macrophages, a mechanism confirmed through both in vitro cell assays and in vivo zebrafish models.
This study demonstrates that predictive action outcomes are incorporated into task representations, thereby increasing the cognitive load required for sustained task maintenance rather than facilitating the switching between task sets.