🧬 biology

Examination of DNA methylation patterns in pancreatic ductal adenocarcinoma

This study analyzes DNA methylation patterns in 62 pancreatic ductal adenocarcinoma patient-derived organoids to identify four distinct methylation-based clusters that reveal tumor heterogeneity and biological processes beyond existing transcriptomic subtypes, potentially guiding future treatment strategies.

Original authors: Joana Ribeiro Pinto, Gun Ho Jang, Amy Zhang, Eugenia Flores-Figueroa, Jingxiong Xu, Parisa Shooshtari, Faiyaz Notta, Robert Grant, Erica Tsang, Grainne O’Kane, Fatemeh Ardakani Behjati, Christopher Pi

Published 2026-08-03

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CC BY 4.0

Original authors: Joana Ribeiro Pinto, Gun Ho Jang, Amy Zhang, Eugenia Flores-Figueroa, Jingxiong Xu, Parisa Shooshtari, Faiyaz Notta, Robert Grant, Erica Tsang, Grainne O’Kane, Fatemeh Ardakani Behjati, Christopher Pin

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ⚕️ This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer

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