4345 papers
This study characterizes the Cooum River in Chennai as a significant environmental reservoir for multidrug-resistant and hypervirulent *Klebsiella pneumoniae*, highlighting the critical public health risks posed by the high prevalence of colistin-resistant strains carrying key virulence genes in urban aquatic ecosystems.
By integrating single-cell and spatial transcriptomics with computational modeling, this study defines a C3-centered multicellular ecology in colorectal liver metastasis characterized by a specific malignant state and stromal-vascular interactions that drive poor prognosis and reveal a MAPK-linked network vulnerability potentially targetable by PD-0325901.
This study demonstrates that the malignant differentiation state of B-cell lymphomas, rather than histological subtype, causally dictates the spatial organization and immune composition of the tumor microenvironment, revealing a shared developmental continuum where dark zone states drive immune depletion and post-germinal center states promote immunosuppression.
This study identifies DIP2C as an independent favorable prognostic biomarker and tumor suppressor in kidney renal clear cell carcinoma (KIRC) through comprehensive pan-cancer bioinformatic analyses and in vitro functional validation demonstrating that its downregulation correlates with poor survival and enhanced cell migration.
This study demonstrates that actin polymerization is essential for the active, temperature-sensitive internalization of diverse tattoo pigments by macrophages, a mechanism confirmed through both in vitro cell assays and in vivo zebrafish models.
This study demonstrates that predictive action outcomes are incorporated into task representations, thereby increasing the cognitive load required for sustained task maintenance rather than facilitating the switching between task sets.
In marine threespine stickleback, developmental temperature induces consistent, family-wide plasticity that lowers the critical thermal minimum in response to cooler early-life conditions, whereas its effect on the critical thermal maximum is minimal and inconsistent across families.
This research proposes a hybrid framework that integrates artificial neural networks with nonlinear dynamical analysis (including phase-space reconstruction, Lyapunov exponents, and Poincaré maps) and copula-based multivariate modeling to achieve highly accurate and reliable automated detection of sleep apnea by capturing both linear and complex breathing patterns.
This large-scale study of 634 polymyxin-resistant bacterial isolates from 28 low- and middle-income countries utilizes whole-genome sequencing and phenotypic testing to reveal the clonal expansion and horizontal gene transfer of high-risk lineages, underscoring the critical need for enhanced genomic surveillance to guide treatment strategies and mitigate the spread of resistance to last-resort antibiotics.
This study demonstrates that experimental neuroinflammation induces cardiac dysfunction through coordinated inflammatory, oxidative, and metabolic stress involving kynurenine pathway dysregulation and impaired autophagy, while revealing that dexamethasone's ability to suppress inflammation and apoptosis is insufficient to prevent cardiac injury or restore autophagic function.