4345 papers
This study reveals that the genetic structure and diversity of peripheral Danube crested newt populations in northern Pannonia are jointly shaped by hybridisation with congeners and riverine connectivity, highlighting the critical role of natural hydrological networks in maintaining evolutionary potential at the species' range margin.
This study validates an autofluorescent reporter cell model that quantifies the conserved induction of lamina-depleted areas (LDAs) across diverse herpesviruses, demonstrating that targeting viral kinase-mediated lamin A/C phosphorylation or cellular isomerase activity effectively blocks this critical nuclear egress step and yields strong antiviral efficacy.
This study demonstrates that Percoll density gradient centrifugation fails to achieve meaningful chromosomal enrichment or improve female calf production in Holstein–Friesian cattle in Indonesia, as evidenced by minimal X:Y shifts in DNA-based assays and comparable field fertility outcomes between sexed and non-sexed semen.
This computational study identifies Beta-Amyrin and Pseudotaraxasterol, two phytocompounds derived from *Glycine max*, as promising potential inhibitors of Estrogen Receptor alpha (ERα) in breast cancer through comprehensive in-silico screening, molecular docking, and stability analyses.
This study demonstrates that while the photosensitizer C7 effectively eradicates planktonic *Salmonella* cells and prevents biofilm formation, its efficacy against established mature biofilms is significantly limited by serotype-specific structural defenses, particularly in strains with robust macrocolony architectures.
A study in South Ethiopia revealed a high trypanosome infection rate (17.1%) among tsetse flies, with *Glossina pallidipes* showing higher prevalence than *G. fuscipes fuscipes*, and identified a diverse range of blood meal sources including humans and dogs, suggesting significant risks for parasite transmission to both livestock and people.
This study identifies significant associations between the GSDMD rs2305492 genetic variant and GSDMC protein levels with prostate cancer, suggesting their potential utility as biomarkers and therapeutic targets.
Contrary to the assumption that invasive species possess inherent competitive superiority, this study reveals that the native ambrosia beetle *Xyleborinus saxesenii* and its fungal symbiont outcompete the invasive *Xylosandrus germanus* in direct interactions, suggesting that the invader's success in Europe is driven by ecological flexibility and repeated introductions rather than competitive dominance.
This study proposes a minimal two-state Monod-Wyman-Changeux dimer model to explain SARM1 regulation by metabolites and the paradoxical activation by orthosteric inhibitors at low doses, reconciling biochemical kinetics, structural data, and cellular assays within a framework of concerted conformational transitions.
This study demonstrates that the cell-free supernatant of *Enterococcus faecium* exhibits potent dual antimicrobial efficacy against bacterial and fungal pathogens through a synergistic combination of metabolites, including organic acids, fatty acids, and bioactive peptides identified via GC-MS and LC-MS-Q-TOF analysis, positioning it as a promising postbiotic candidate for functional foods and antimicrobial applications.