4345 papers
Transient inhibition of microglial proliferation during late embryonic development establishes a lifelong, sex-dependent state in the spinal cord that alters homeostasis, behavior, and myelin architecture, ultimately reprogramming the tissue's functional and transcriptional responses to injury in adulthood.
This study utilized wastewater metagenomics across 62 cities in 38 countries to map the global diversity of hepatitis A and E viruses, revealing widespread zoonotic rat HEV transmission and demonstrating the value of sewage surveillance for monitoring both human and animal hepatitis strains.
This study employs a multi-locus genome-wide association study across 239 maize inbred lines to elucidate the genetic architecture of kernel fat content, identifying 200 significant QTNs and prioritizing the plastid-localized quinone-oxidoreductase gene *Zm00001d025166* as a key candidate for marker-assisted selection in high-oil maize breeding.
This study presents the first draft genome of the exclusively freshwater Amazonian manatee (*Trichechus inunguis*), revealing a smaller genome size than its marine relatives and identifying expansions in gene families related to G-protein-coupled receptor signaling, ion channels, and oxidative metabolism that likely underpin its adaptation to the Amazonian environment.
Corilagin alleviates age-related cognitive deficits and neuroinflammation in mice by directly targeting V-ATPase B2 to restore the lysosomal Ca²⁺-AMPK metabolic axis, thereby suppressing microglial overactivation and protecting neuronal function.
This study demonstrates that current Perturb-seq benchmarks, constrained by a small overlap between curated regulatory references and measured genes, lack sufficient statistical power to distinguish whether causal inference methods successfully recover direct regulatory edges from matched random rankings.
This study demonstrates that the performance gap between random and spatial cross-validation in spatial transcriptomics is primarily driven by class-support mismatches rather than spatial leakage, revealing that graph neural networks incur a significantly larger genuine spatial-extrapolation penalty than non-graph classifiers once confounding factors are rigorously controlled.
This study presents a self-consistent, unvalidated simulation framework combining mechanistic ODE models and an LSTM surrogate to predict the safety of gene-delivery protocols for reducing arrhythmia risk under vascular stress, while explicitly distinguishing chronic therapeutic effects from acute electroporation injury and acknowledging the need for future experimental validation.
This study of the All of Us database reveals that the lifetime penetrance of the Parkinson's disease-associated LRRK2 G2019S variant is approximately 38%, with family history identified as a major risk factor and specific genetic modifiers, such as the protective N551K-R1398H-K1423K haplotype, influencing disease manifestation.
This network analysis study of 214 healthy adults reveals that interoceptive awareness, particularly its regulatory and interpretive dimensions, exhibits strong, direct connections to cognitive empathy but only weak, indirect associations with Theory of Mind and facial emotion recognition, highlighting the multidimensional and differential nature of interoception's role in social cognition.