4345 papers
This study reveals that while renal cell carcinoma patients exhibit distinct urinary microbiota changes, significant microbial dysbiosis and the enrichment of *Treponema* are primarily localized within the tumor microenvironment of metastatic patients, suggesting a compartment-specific microbial signature associated with disease progression.
This EEG study demonstrates that immersive virtual reality observation of a complex Karate Kata elicits significantly greater central mu rhythm suppression in novices compared to both live and 2D video observation, suggesting IVR's superior potential for engaging sensorimotor systems in motor training and rehabilitation research.
This study reveals that stress granules act as protective guardians against inflammation by rapidly sequestering double-stranded RNA released from fragmented mitochondria, thereby disrupting a self-amplifying PKR-DRP1 feedback loop that drives mitochondrial damage and chronic inflammatory diseases.
This study demonstrates that injury-induced upregulation of the Sema6C/PlexinA2 signaling pathway drives remote neuronal apoptosis and functional impairment in the adult CNS through JNK activation and neuroinflammation, identifying it as a promising therapeutic target for limiting secondary neurodegeneration.
This study reveals that while bromide availability is strictly required for the production of the neurotoxin aetokthonotoxin in *Aetokthonos hydrillicola*, the long-term transcriptional regulation of its biosynthetic gene cluster is decoupled from toxin synthesis and instead governed by an interplay between nitrogen limitation and global regulators like NtcA.
This study demonstrates that exposing porcine intestinal organoids to post-operative fecal supernatants from infants with congenital heart disease undergoing cardiopulmonary bypass induces epithelial barrier dysfunction and injury through pro-inflammatory microbial shifts, eicosanoid dysregulation, and PGE2-axis remodeling.
This multi-omics cohort study of 18 fatal visceral gout cases across three crocodilian species establishes that the disease is driven by a cascade of purine metabolic collapse, antioxidant defense failure, and irreversible mitochondrial injury, while revealing significant species-specific variations in metabolic susceptibility.
This study demonstrates that a *Lacticaseibacillus paracasei* postbiotic, specifically via the cofactor 10-formyl-tetrahydrofolate, rescues glucose-impaired serotonergic signaling and improves physiological outcomes in *C. elegans*, an effect that is specifically antagonized by unmetabolized folic acid under glucose stress.
This multi-omic study identifies vasorin (VASN) as a novel, reproducible biomarker of cardiometabolic health in children with obesity, demonstrating consistent associations across genomic, epigenomic, transcriptomic, and proteomic layers that support its potential for early risk stratification in precision prevention strategies.
The probiotic mixture Golden Bifid (BSL) alleviates high-fat diet-induced obesity and dyslipidemia in mice by reshaping the gut microbiota and modulating lipid metabolism through the suppression of the FABP2-PPAR axis and regulation of key genes like HMG-CoA reductase and LXR-α.