4345 papers
This study demonstrates that in breast cancer, aldehyde stress driven by cancer stem cells and CD8⁺ T cell exhaustion are compartmentally decoupled, with tumor exclusion mediated by spatial segregation and protein checkpoint signaling rather than diffusible metabolites, suggesting that effective treatment requires a dual strategy targeting both CSC metabolism and T-cell restoration.
This exploratory genome-wide association study in an admixed Brazilian cohort identifies a significant genetic variant at the PASD1 locus (rs56035326) associated with reduced COVID-19 severity, marking the first evidence linking this gene to disease outcomes in such populations.
This study investigates the combined genotoxic and transcriptional effects of chronic low-dose-rate gamma irradiation and inorganic arsenite in CBA and C57BL/6 mice, revealing that while irradiation is the dominant stressor, concurrent arsenite exposure primarily induces oxidative DNA damage with non-additive or counteracting effects on gene expression and minimal strain-specific interactions.
This study utilizes TMT-based proteomics, OCT, and ERG to identify early retinal pathological changes and differentially expressed proteins in an AlCl3/D-gal-induced sporadic Alzheimer's disease mouse model, revealing significant retinal thinning and functional deficits alongside memory impairment.
This study reveals that while purifying selection is the dominant force maintaining mitochondrial function in Ethiopian *Lophuromys* rats, high-altitude adaptation involves rare, lineage-specific positive selection on protein-coding genes and likely relies on a combination of localized mitochondrial changes and alternative physiological mechanisms rather than widespread adaptive introgression.
This study demonstrates that EEG microstate analysis applied during naturalistic movie-watching can effectively capture empathy-related brain dynamics, revealing distinct condition-dependent patterns that correlate with event-related potentials, prosocial behavior, and trait empathy, thereby extending the method's utility beyond resting-state and clinical research.
This paper introduces STAR, a few-shot molecular property prediction framework that leverages assay descriptions as language priors to guide task selection and feature modulation, significantly improving performance on label-scarce datasets by complementing structural data with biological context.
This study systematically evaluates the genetic associations of 123 RNA modification enzymes with psychiatric disorders, identifying *NSUN2* and several other candidates as significant risk genes for bipolar I disorder and schizophrenia, with findings suggesting a consistent pattern of downregulation in patient brains.
This cross-sectional study of 302 pre-medical students in Punjab, Pakistan, reveals that high levels of academic stress associated with MDCAT preparation are significantly correlated with increased perceived cognitive difficulties and poor sleep quality, supporting the hypothesis that chronic academic pressure adversely affects neurobiological and cognitive functioning even before medical school entry.
This study addresses the critical issue of noise-induced fatigue in high-speed train drivers by developing a dual-modal PPG-EEG detection system that reveals a "central inhibition–peripheral compensation" mechanism and introduces a novel Dual-modal Integrated Fatigue Index (DIFI) with a three-level intervention strategy, achieving a 10.6% performance improvement over single-modal methods.