4345 papers
This study demonstrates that in Acute-on-Chronic Liver Failure (ACLF), reproducible disease-associated biology is more robustly captured by coordinated alterations in lipid classes and modules than by individual lipid species, revealing specific lipid programs linked to organ failure severity and shared critical illness mechanisms.
This study presents a high-quality chromosome-level genome assembly of the Tibetan brown bear, revealing its demographic history of population expansion and bottlenecks, as well as a unique carbohydrate-dominated metabolic adaptation for hibernation that distinguishes it from North American brown bears.
This study demonstrates that Wolbachia-mediated dengue control in *Aedes aegypti* remains robust and effective despite sublethal insecticide exposure, as the symbiont's density, pathogen blocking, and reproductive traits rapidly recover without compromising viral suppression.
This study identifies CcF-box SNE as a key negative regulator of leaf size in pepper that restricts leaf development by modulating cell expansion, hormone homeostasis, and photosynthetic efficiency.
This study characterizes azole-resistant *Candida* species isolated from women with vulvovaginal candidiasis in Ibadan, Nigeria, revealing a high prevalence of fluconazole resistance and identifying specific mutations in the *erg2* and *erg11* genes that underscore the urgent need for molecular surveillance to guide local treatment guidelines.
This study demonstrates that single-cell foundation models can predict durable CAR T-cell persistence in pediatric B-ALL patients from pre-infusion scRNA-seq data with high accuracy, achieving clinically actionable insights even without perfect cell annotation and identifying CD8+XCL1/2+ cells as a key biomarker for long-term response.
This study demonstrates that encoding intermittent parathyroid hormone signals into preconditioned stem cell-derived exosomes and delivering them via a thermosensitive hydrogel effectively repairs osteoporotic bone defects by simultaneously promoting osteogenesis and angiogenesis, restraining osteoclastogenesis, and modulating the inflammatory microenvironment through the activation of the PA-PLD-LATS1/YAP signaling axis.
This study demonstrates that periodontal ligament stem cells suppress macrophage-driven inflammation and promote oral tissue healing by reprogramming pyrimidine metabolism to inhibit NLRP3 inflammasome activation, a mechanism validated by the therapeutic efficacy of the pyrimidine precursor triacetyluridine.
By analyzing over 9,000 mitogenomes, this study reveals that fine-scale maternal genetic structure and recent population expansions in the Circum-Baltic region were significantly shaped by Bronze and Iron Age demographic processes, uncovering distinct trajectories such as Sweden's post-Bronze Age recovery and a previously overlooked maternal genetic link between Estonia and Finland.
J-AST is a free, open-source, web-based platform that automates and unifies the analysis of disk diffusion assays and Etests for antimicrobial susceptibility testing, offering high accuracy in resistance quantification and metadata management to support both research and clinical workflows.