🧬 Category

q-bio

4401 papers

🧬 biology

Diagnosing Simulation and Hardware Barriers to Cross-Size Transfer in Equivariant Quantum Reinforcement Learning

This paper demonstrates that while equivariant quantum reinforcement learning policies trained on small combinatorial optimization instances can outperform size-matched training in zero-shot transfer to larger instances within idealized regimes, their performance on realistic hardware is severely degraded by simulation truncation, conditional performance bounds, and shot-noise limitations, ultimately establishing a rigorous diagnostic standard for future claims of quantum advantage.

Monit Sharma, Hoong Chuin Lau2026-07-30
🧬 biology

The role of IL-1β/IL-1Ra mediated olfactory ensheathing cell injury in olfactory dysfunction in OVA-induced allergic rhinitis mice

This study demonstrates that ovalbumin-induced allergic rhinitis causes olfactory dysfunction in mice by activating microglia to elevate IL-1β levels, which subsequently damages olfactory ensheathing cells and impairs olfactory bulb neurogenesis, a mechanism reversible by IL-1 receptor inhibition.

Xiaoyu Song, Hanrui Wang, Yakui Mou, Wanchen Liu, Ting Yang, Yao Wang, Mingjun Zhang, Yuanchao Cheng, Chao Ren, Shizhuan (…)2026-07-30
🧬 biology

Integrating WGCNA, machine learning, and single-cell sequencing analysis to elucidate the molecular mechanism of SREBF1 in Alzheimer’s disease: evidence from Mendelian randomization and exploration of potential therapeutic agents targeting SREBF1 via molecular docking

This study integrates multi-omics analyses, Mendelian randomization, and molecular docking to identify SREBF1 as a causal driver of Alzheimer's disease through immune cell regulation and oligodendrocyte dysfunction, while proposing efavirenz as a potential therapeutic agent targeting this gene.

Jihao Xue, Qijia Yin, Xinze Li, Luotong Liu, Jianguo Xu, Qitai Song, Ming Wang2026-07-30
🧬 biology

Conserved lifestyle-associated chromosome architectures across mammalian symbionts

This study reveals that obligate mammalian symbionts maintain a stable, host-attached longitudinal chromosome orientation regardless of ploidy while dynamically remodeling their higher-order genome architecture in response to specific physiological states and environmental contexts.

Silvia Bulgheresi, Tobias Viehboeck, Nicole Krause, Philipp Weber, Eanna O'Shea, Valentin Noetzel, Nika Pende, Hanna Goe (…)2026-07-30
🧬 biology

FLT3-ITD signals for CEBPA and p53 proteolysis by the ubiquitin-proteosome pathway

This study demonstrates that FLT3-ITD mutations in acute myeloid leukemia drive the ubiquitin-proteasome-mediated degradation of the tumor suppressors CEBPA and p53 via phosphorylation-dependent interactions with UHRF1 and USP7, revealing that proteasome inhibitors can effectively restore these proteins and induce cell death even in tyrosine kinase inhibitor-resistant cases.

Yogen Saunthararajah, Xiaorong Gu, Sudipta Biswas, Zeinab Zahran, Songa Bae, Ramesh Balusu, Babal Jha, Jaroslaw Maciejew (…)2026-07-30
🧬 biology

A comprehensive RNA-seq dataset of embryonic and larval development in Senegalese sole (Solea senegalensis) across three thermal regimes

This study presents a high-quality RNA-seq dataset comprising 48 samples of Senegalese sole embryonic and larval development across eight stages under three temperature regimes, providing a foundational resource for investigating thermal plasticity, developmental regulation, and aquaculture applications in flatfish.

Lourdes Vega, Daniel Ramirez, Ismael Cross, Oscar Aramburu, Dorinda Torres-Sabino, Maialen Carballeda, María Esther Rodr (…)2026-07-30