4401 papers
This study identifies novel, highly abundant testis-specific gene transcripts, particularly *pmfbp1*-like, as robust environmental RNA markers for detecting fish reproductive behavior through non-invasive water sampling.
This study integrates single-cell and bulk transcriptomic data to identify five ubiquitination-related biomarkers (MYC, TLR7, CX3CR1, PER1, and GADD45B) involved in osteoarthritis pathogenesis, revealing their enrichment in the TNF-alpha/NF-kappaB pathway, association with specific immune cell populations, and elevated expression in synovial fibroblasts, thereby offering novel therapeutic targets for the disease.
This study demonstrates that *Agrobacterium rhizogenes*-induced transformed callus of *Panax vietnamensis* serves as a stable, hormone-free, and highly productive alternative to hairy roots for the sustainable in vitro production of the rare saponin majonoside R2, particularly when enhanced by MeJA elicitation.
This study introduces a polarity-registered nuclear coordinate system that normalizes nuclear geometry to reveal discrete, reproducible topological classes of chromosome organization in human mesenchymal stem cells, demonstrating that mechanical and polarity constraints drive asymmetric, homolog-specific spatial behaviors.
This study reveals that elevated BMP9 expression drives hepatocellular carcinoma progression by promoting CKS1B-K4 lactylation, which enhances CKS1B interaction with CDK1–3 and facilitates p27 degradation to accelerate cell cycle progression.
FuncDECODE is a computational framework that leverages single-cell references to deconvolve mixed bulk and spatial transcriptomic data, thereby enabling the identification of cell-type-specific functional program remodeling across diverse biological states, disease contexts, and spatial tissue architectures.
This study identifies PfAP2-HCR as an essential ApiAP2 transcription factor in *Plasmodium falciparum* that orchestrates host cell remodeling by directly regulating the expression of key exported proteins, thereby ensuring parasite survival, development, and transmission through both asexual and sexual blood stages.
The paper introduces Neural Transcriptomic Field (NTF), a deep learning framework that leverages implicit neural representations to achieve ultra-fast, scalable, and high-fidelity 3D reconstruction of spatial omics data from sparse 2D slices, enabling the rapid generation of comprehensive tissue atlases with inherent denoising and super-resolution capabilities.
This study reveals that sex-specific differences in FGF signaling, characterized by higher FGF1 levels in females and higher decoy receptor FGFRL1 expression in males, differentially regulate the balance between adipogenesis and osteogenesis, thereby contributing to skeletal sexual dimorphism and offering a potential therapeutic target for age-related bone loss.
This study demonstrates that TMC5 promotes lung adenocarcinoma progression by upregulating epithelial-mesenchymal transition (EMT), thereby enhancing cell proliferation, migration, and invasion, which suggests its potential as a diagnostic and therapeutic target.