4401 papers
This study presents cryo-EM structures of the full-length human VPS4B hexamer in spiral staircase states, revealing how specific MIT domain interactions and linker peptide occupancy drive substrate-dependent hexamerization and priming for ESCRT-III remodeling.
This study demonstrates that ranitidine hydrochloride, but not tiapride, induces significant autophagy characterized by increased LC3-II expression, decreased HSP70 expression, and polycystic vesicle formation in A549 cells and mouse bone marrow cells.
This study reveals that in Nanjing's Zijin Mountain, recreational use alters ground-active arthropod assemblages not by reducing total abundance, but by concentrating dominance in specific taxa like ants, reducing diversity, and shifting functional traits and community composition through the degradation of the litter layer.
This study demonstrates that S100A11 promotes tenocyte-derived stem cell apoptosis and impairs tendon healing by interacting with UCHL3 to dysregulate the Bcl-2/Bax/Caspase-3 signaling pathway, suggesting that inhibiting S100A11 could serve as an effective therapeutic strategy for tendinopathy.
The authors developed a tightly regulated, genome-integratable inducible expression platform based on an optimized cumate gene-switch system to precisely model cMET oncogene variants in A549 cells, enabling accurate functional characterization and drug sensitivity profiling for targeted cancer therapies.
This study reveals that lithium's mood-stabilizing effects in bipolar disorder arise from a coordinated reorganization of multi-kinase phosphorylation networks in mouse synapses, rather than single-target inhibition, with these lithium-sensitive pathways showing significant enrichment in bipolar disorder genetic risk loci.
The paper introduces Syn-PALM, a robust and scalable linear mixed model framework that leverages machine learning-predicted synthetic proteomic data to significantly enhance statistical power and genetic discovery in genome-wide association studies despite substantial missingness in biobank datasets.
The paper introduces Interaction-Token Structural Alignment (ITSA), an interpretable framework that converts protein structures into residue-level biochemical interaction tokens for local alignment, demonstrating its effectiveness in capturing family-level similarity and preserving mechanistic context where traditional geometry-focused methods fall short.
This paper proposes a quantum-biogenesis model where thermally methylated sulfur complexes align within diamagnetic magnesium-silver matrices to create magnetic gradients that template the self-assembly and autonomous division of proto-cellular membranes.
This study introduces Multifractal Space-filling Curve Analysis (MFSCA) to demonstrate that the spatial organization of brain structures, as measured by multifractality in MRI data, progressively deteriorates from a complex, heterogeneous state to a simpler, homogeneous one with advancing age and the progression of dementia.