4401 papers
This study challenges the prevailing view that Human Endogenous Retroviruses (HERV-K) are inactive by demonstrating that the HERV-K10 element actively retrotransposes in human cancer cells and immature oocytes, where this process drives genomic instability and induces aggressive, metastatic cancer stem cell-like characteristics in glioblastoma.
This study demonstrates that in an ASD mouse model carrying the R451C Neuroligin-3 mutation, impaired resolution of striatal inflammation drives synaptic and behavioral deficits through lipidomic and glial dysregulation, which can be fully reversed by environmental enrichment that restores endogenous inflammatory resolution pathways.
By analyzing high-resolution spatial transcriptomics data from Alzheimer's disease brains, this study identifies a precise 25 μm spatial threshold where myeloid cells abruptly transition from a homeostatic to a disease-associated state, revealing specific early-warning biomarkers and regulatory drivers within this critical event horizon.
This paper introduces a Shannon entropy-partitioning framework for open flow networks to reveal an "organization–adaptability window," finding that while most natural ecosystems occupy this optimal state, urban systems typically fail to do so due to insufficient boundary exchange diversity relative to internal flow disorder.
This systematic review synthesizes genome-wide selection-signature evidence from 58 studies to identify a reproducible core of candidate genes in tropical *Bos indicus* cattle that govern both climate adaptation (thermotolerance and immunity) and production traits, providing priority targets for breeding strategies that enhance resilience without compromising productivity.
This systematic review of 28 studies identifies 17 genetic variants across eight populations associated with on-water sports performance but concludes that current evidence is insufficient for meta-analysis, highlighting the need for larger, diverse, and collaborative genome-wide studies to fully understand the genetic basis of athletic success in these disciplines.
This study demonstrates that field-relevant sub-lethal doses of the pesticide imidacloprid induce structural and expression changes in both presynaptic and postsynaptic cholinergic components of the nervous systems in honey bees and nematodes.
This study computationally screens human brain enzymes for radical pair mechanism (RPM) competence, finding that while eight of nine candidates meet necessary spin-parameter conditions, severe quantitative barriers—specifically prohibitive exchange coupling requirements and short coherence times—effectively rule out RPM-based magnetic field sensitivity in neurotransmitter-metabolizing enzymes, leaving cryptochrome as the sole defensible RPM host.
This study isolated and identified five novel compounds from the Iranian plant *Astragalus aegobromus*, demonstrating through molecular docking that they exhibit favorable binding affinities to estrogen receptors, thereby suggesting their potential as estrogen receptor modulators pending further biological validation.
This study demonstrates that human pluripotent stem cell-derived hemangio-organoids can be efficiently differentiated via a scalable, non-genetic protocol into functional dendritic cells capable of stimulating T-cell responses, highlighting their potential as a source for immune cell therapies in regenerative medicine.