q-bio papers | Gist.Science

The inflammatory paradox of TLR4/NF-κB signaling in canine transmissible venereal tumors: why a protumoral pathway is associated with tumor stabilization

This review proposes that the TLR4/NF-κB pathway paradoxically promotes canine transmissible venereal tumor stabilization rather than progression by reprogramming inflammatory signaling to suppress tumor survival mechanisms and recruit effector immune cells, while highlighting critical research gaps and suggesting experimental strategies to validate this mechanism.

Ulisses Nilo Landi, Rita de Cássia Lima Ribeiro, Nickole Mendes Gonçalves, Cayo César Novais Zanatto, Daniel Barreto Mas (…)2026-07-30

🧬 biology

An Epigenetic Regulatory Hubin Nasopharyngeal Carcinoma: Coordinated Action of DNMT1, EZH2, HDAC2, SMARCA4, BRD4, and H19during Regional Progression

This study identifies a coordinated, stage-dependent epigenetic regulatory hub comprising DNMT1, EZH2, HDAC2, SMARCA4, BRD4, and H19 that orchestrates the chromatin and metabolic reprogramming driving regional progression in nasopharyngeal carcinoma.

Antonio Romeu, Maria-Jose Oliach2026-07-30

🧬 biology

Isolation and Characterization of PET-Degrading Bacteria from Plastic Waste- Contaminated Soil in Western India

This study identifies and characterizes native PET-degrading bacteria, primarily *Pseudomonas* and *Stutzerimonas* species, from plastic-contaminated soils in Western India, demonstrating their potential for bioremediation in both terrestrial and high-salinity environments.

Rinkal Kachhadia, Suchismita Shrivastav, Hiral Chavada, Sulagna Roy, Milind Kulkarni2026-07-30

🧬 biology

Host microbial lifestyle shapes diversity in the vastly underrepresented global Porifera plasmidome

This study analyzes 526 marine sponge metagenomes to reveal that host microbial lifestyle (HMA vs. LMA) strongly shapes a vast, previously overlooked plasmid reservoir that significantly contributes to sponge holobiont adaptation, defense, and functional plasticity.

Başak Öztürk, Barbara Cania, Kristina Bayer, Tal Dagan, Ute Hentschel, David Ngugi2026-07-30

🧬 biology

Community context, resource dynamics, and body size differences shape multidimensional niche overlap among avian frugivores in South Asian tropics

This study demonstrates that multidimensional niche overlap among avian frugivores in South Asian tropical forests is shaped by competition, local resource availability, and body-size differences, with greater species richness driving stronger niche differentiation to facilitate coexistence.

Rintu Mandal, Himanshu Lad, Natasha Desai, Rasika Kadam, Anand M. Osuri, Rohit Naniwadekar2026-07-30

🧬 biology

Dietary Tryptophan Restriction Remodels the Skin Metabolic Environment and Drives Microbial Community Restructuring

This study demonstrates that dietary tryptophan restriction remodels the skin's metabolic environment by altering host-microbial metabolic pathways and AhR signaling, which in turn drives significant, tissue-specific restructuring of the skin microbiota without affecting steady-state immune cell composition.

Viviane A Agbogan, Pedro Goncalves, Camille Dupuy, Antoine Lefevre, Patrick Emond, Lydie Nadal-Desbarats, Nicolas Serafi (…)2026-07-30

🧬 biology

Expanding the Green Algal Flora of Brazil: New Records of Chlorophyta from Paraná Streams

This study documents 93 Chlorophyta taxa from nine streams in western Paraná, Brazil, including 32 new records for the region and nine new records for the country, thereby significantly expanding the known green algal flora of the area.

Ionara De Souza Neis, Patrícia Iatskiu, Norma Catarina Bueno2026-07-29

🧬 biology

Data Source Heterogeneity, Not Algorithm Choice, Drives Performance Gaps in QSAR for Mutagenicity

This study demonstrates that data source heterogeneity, rather than algorithm choice, is the primary driver of performance gaps in QSAR models for mutagenicity, necessitating a shift toward source-aware evaluation standards to ensure reliable regulatory risk assessment.

Seungmin Yoon, Sanghun Kim, Hyunpyo Jeon2026-07-29

🧬 biology

In Vitro Assessment of Cell Proliferation and Migration Induced by Crude Lychee Seed Extract in Human Gingival Fibroblast Cells (HGF-1)

This study demonstrates that crude lychee seed extract, rich in phenolics and flavonoids, is non-cytotoxic to human gingival fibroblasts at concentrations up to 50 µg/mL and significantly enhances cell proliferation and migration in a concentration-dependent manner, suggesting its potential as a therapeutic agent for promoting oral wound healing.

Titikan Ruensukon, Boontharika Chuenjitkuntaworn, Tasanee Tengrungrungsun, Praewpat Pachimsawat, Yukihiko Tamura, Pornpo (…)2026-07-29

🧬 biology

Numerical Optimization Strategies for the Variational Hamiltonian Ansatz in Noisy Quantum Environments

This study demonstrates that while gradient-based optimizers excel in noiseless simulations, population-based strategies like CMA-ES are significantly more robust against finite-shot sampling noise in Variational Hamiltonian Ansatz calculations, and that high-shot reevaluation can effectively mitigate sampling-induced fluctuations to recover accurate energy estimates.

Silvie Illésová, Vojtěch Novák, Tomáš Bezděk, Clemens Sauer Possel, Martin Beseda2026-07-29

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