4401 papers
This study demonstrates that coinfection of *Ixodes ricinus* ticks with specific bacterial species differentially modulates Tick-borne encephalitis virus (TBEV) replication and triggers distinct, species-specific activation patterns of the Toll, IMD, and JAK/STAT immune signaling pathways.
This study demonstrates that a "Tag-and-Trigger" paradigm, which combines spatial learning with precisely timed basolateral amygdala stimulation, rescues memory deficits, restores synaptic plasticity, and reverses Alzheimer's pathology in 5XFAD mice by leveraging activity-dependent mechanisms to reinforce specific hippocampal-cortical circuits.
This study presents the first high-quality, de novo reference genome for the economically and ecologically vital Argentine hake (*Merluccius hubbsi*), which not only elucidates its evolutionary history and demographic fluctuations but also confirms its current robust genetic diversity and lack of recent inbreeding despite historical climate changes and intense fishing pressure.
This study identifies the m6A reader IGF2BP2 as a critical regulator of the HMGA2/FOSL1 axis that drives the adrenergic-to-mesenchymal transition, chromatin remodeling, and therapy resistance in high-risk neuroblastoma, thereby revealing epitranscriptomic and transcriptional vulnerabilities for therapeutic intervention.
This study analyzed 125 culture-confirmed *Vibrio cholerae* isolates from Ethiopian cholera outbreaks using multiplex PCR and found that all nine targeted virulence-associated genes were present across the isolates, with *hlyA* being the most prevalent, thereby highlighting the significant pathogenic potential of circulating strains and establishing a molecular baseline for future epidemiological research in the region.
This study demonstrates that delivering a stabilizing nanobody (T2a) via mRNA lipid nanoparticles corrects F508del-CFTR trafficking and reveals a novel, non-canonical open-channel conformation, offering a new therapeutic paradigm for cystic fibrosis and other protein misfolding diseases.
This study demonstrates that intravenous administration of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) attenuates neurogenic degeneration and behavioral abnormalities in an infantile acute encephalopathy mouse model by suppressing neuroinflammation and modulating microglial activation.
This study demonstrates that Fragile X syndrome is characterized by region-specific alpha reactivity deficits and distributed network alterations without global alpha slowing, supporting a multi-system model of dysfunction where these dynamics serve as a promising translational biomarker.
This study reveals that TopBP1 condensates act as central architectural hubs that orchestrate nuclear actin assembly and nuclear envelope integrity via ATR-mTOR signaling to maintain genome stability during replication stress, a mechanism that is hijacked by chemo-resistant colorectal cancer cells to promote survival.
Through computational simulations, this paper argues that the brain's valuation system is evolutionarily designed to generate diverse, non-arbitrary subjective values through stochastic learning and resonance, thereby establishing that subjectivity possesses an underlying objective basis.