q-bio papers | Gist.Science

Effects of Landscape Change on Habitat Suitability for Iberian Large Carnivores: Current Trends and Future Scenarios

This study assesses how past and future land-use changes impact habitat suitability and connectivity for the Iberian wolf, brown bear, and Iberian lynx, revealing that while overall habitat availability has remained stable, agricultural intensification poses a severe future threat by increasing fragmentation and reducing connectivity, whereas rural abandonment offers potential improvements.

Felipe Pacheco Spirlandelli, Francisco Álvares, João Gonçalves, Sergio González-Ávila, João C. Azevedo2026-07-29

🧬 biology

Spreading of α-synuclein rewires organelle communication and disrupts neuron-astrocyte mitochondrial quality control

This study reveals that spreading α-synuclein accumulates at tri-organelle contact sites to stabilize and rewire organelle communication, thereby impairing neuron-astrocyte mitochondrial quality control by disrupting mitochondrial transfer to astrocytes.

Melissa Birol, Elisabeth Fritsch, Kamelija Horvatovic, Paula Santos Otte, Tomas Koudelka, Jana Rossius, Caroline Braeuni (…)2026-07-29

🧬 biology

Normative modeling in neuroimaging across psychiatric and neurological disorders: a systematic review and the NORMA reporting checklist

This systematic review of 122 neuroimaging studies highlights the shift toward individualized normative modeling in psychiatry and neurology, identifies critical gaps in empirical foundations and reporting transparency, and introduces the 18-item NORMA checklist to standardize model construction, validation, and clinical application.

Shinichiro Luke Nakajima, Naoki Takamatsu, Issei Ueda, Yoshito Saito, Yusuke Takahashi, Takahide Etani, Shunsuke Tamura (…)2026-07-29

🧬 biology

Modeling survival–diversity trade-offs and rearrangement cascades in synthetic yeast SCRaMbLE

This study introduces a risk-aware stochastic framework to model survival–diversity trade-offs in synthetic yeast SCRaMbLE, revealing how event probabilities and rearrangement types (such as inversions and duplications) influence viability selection and structural diversity while identifying optimal parameters for balancing clone survival with genomic variation.

Yaojun Zhu2026-07-29

🧬 biology

Mouse genetic mosaic model for basal-like breast cancer reveals disruption of basal-myoepithelial architecture at premalignancy

Using a MADM mouse model, this study reveals that the disruption of the basal-myoepithelial cell layer is an early hallmark of basal-like breast cancer progression, occurring during hyperalveolarization and preceding malignant transformation, with this architectural breakdown strongly linked to the expression of the basal marker Keratin 14 in premalignant luminal cells.

Alexys T. Riddick, Xian Zhou, Hui Zong2026-07-29

🧬 biology

Transcriptome and Co-expression Network Analysis Reveals Key Modules and Hub Genes Controlling Husk Number in Maize

This study integrates transcriptome and co-expression network analyses to identify key gene modules and hub genes, revealing that a brassinosteroid–MAPK–cell cycle regulatory program drives increased husk number in maize.

Xitong Xu, Dusheng Lu, Yancui Wang, Yanbin Han, Haixiao Su, Lifan Shi, Cuixia Chen2026-07-29

🧬 biology

Yhk8 as a genomic modifier of copper susceptibility in yeast

This study identifies Yhk8, a putative drug/proton antiporter, as a novel genetic modifier of copper susceptibility in yeast by demonstrating that its deletion impairs growth and elevates superoxide levels across diverse genetic backgrounds.

Valeria Olguín, Sofia Contreras, Francisca Arriagada, Javier Saavedra, Benjamín Szenfeld, Francisco A. Cubillos, Andrés (…)2026-07-29

🧬 biology

Hebbian Consolidation during Sleep Drives the Semantization of Episodic Sequences: A Neurocomputational Model

This paper presents a biologically grounded neurocomputational model demonstrating that Hebbian consolidation during non-REM sleep transforms context-bound episodic sequences into generalized semantic representations, while REM sleep fosters fragmented, creative associations through cortical disengagement and noise.

Mauro Ursino, Elisa Valgimigli, Gabriele Pirazzini2026-07-29

🧬 biology

Molecular Heterogeneity of Breast Milk in Intestinal Development: A Multi-Omics Approach Using Human Organoids and Caco-2 Cells

This study utilizes a multi-omics approach with human small intestinal organoids to reveal that breast milk from different donors drives distinct molecular pathways related to immune function and development, demonstrating organoids as a superior model over Caco-2 cells for understanding breast milk's role in infant gut maturation and guiding future formula development.

Xianli Wang, Yao Yang, Dongxu Wei, Chendong Zheng, Yuxin Jing, Chenxuan Huang, Haiyang Yao, Zening Wang, Kainan Huang, J (…)2026-07-29

🧬 biology

Focal ventromedial prefrontal stimulation modulates working memory-related functional connectivity under elevated arousal

This study demonstrates that focal anodal stimulation of the ventromedial prefrontal cortex improves working memory performance under elevated arousal by modulating task-related functional connectivity between attention-regulatory and sensory-processing brain regions.

Sumit Roy, Rana Gueler, Maren Claus, Emilio Chiappini, Michael Burke, Thomas Kleinsorge, Erhan Genc, Michael Nitsche2026-07-29

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