q-bio papers | Gist.Science

The Posterior Cerebellum’s Role in Feeling Moved by Visual Art: A Transcranial Direct Current Stimulation Approach

This study investigates the role of the posterior cerebellum in aesthetic experiences by using transcranial direct current stimulation (tDCS) to reveal that anodal stimulation modulates feelings of being moved by art in complex ways, specifically increasing emotional engagement for individuals with low art experience and low-to-medium empathy while decreasing it for those with high art experience.

Ryan Joseph Slaby, Matthew Pelowski2026-07-29

🧬 biology

Provenance-aware observations of mitochondrial organization

This paper introduces "armosis," a quantitative framework measuring the progressive reduction in theoretically possible biological entities across organizational levels, and demonstrates its application using a provenance-aware knowledge graph of human mitochondrial genomes to reveal increasing constraints from codons to the complete electron transport chain.

David A Stumpf2026-07-29

🧬 biology

ResNet50 Features for Colon Histopathology: What Transfer Learning Actually Delivers

This paper evaluates the efficacy of frozen ResNet50 features for colon histopathology, finding that while transfer learning yields near-perfect detection accuracy and biologically plausible clustering, it does not eliminate the critical need for stain normalization, external validation, and explainability to address potential data leakage and bias.

Samjhana Shakya2026-07-29

🧬 biology

Epigenetic Age Estimates in Blood Shift by Decades with Cell Population: A Within-Donor Variance Partition Across Two Platforms and Two Study Designs

This study demonstrates that epigenetic age estimates in blood vary by decades depending on the specific cell population assayed, a variation large enough to dominate biological signals and confound cross-study comparisons, thereby establishing cell composition as a critical methodological variable that requires standardized reporting.

Frederic Scheer2026-07-29

🧬 biology

Water-Mediated Mechanical Coupling Governs T-Cell Discrimination in HLA-B*35

This study reveals that the Arg156 polymorphism in HLA-B*35 enables T-cell discrimination not through static binding affinity, but by organizing a structured water-mediated electrostatic network that suppresses peptide flexibility and lowers the entropic penalty required for T-cell receptor triggering.

Yasir Arafat Maassoom2026-07-29

🧬 biology

AI Driven Analysis of Canola Rhizosphere Microbiome: Diversity, Core Microbiome, and Machine Learning Classification

This study analyzes the canola rhizosphere microbiome using 16S rRNA sequencing of 8,701 samples to characterize diversity and identify a core microbiome, ultimately developing a highly accurate Random Forest classifier based on ASV features to predict plant health status.

Zariab Ahmed, Amina Shoukat Amina Shoukat, Saqib Hussain Hadri, Abdullah Tariq Abdullah Tariq2026-07-29

🧬 biology

Reorganization of lateral orbitofrontal neuronal ensembles underlies pain-related impairment of delayed gratification

This study demonstrates that chronic inflammatory pain impairs delayed gratification in rats by reorganizing the functional ensembles of lateral orbitofrontal cortex neurons, rather than simply reducing their overall activity, thereby disrupting the population coding of time-reward associations.

Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cruz2026-07-29

🧬 biology

Identification and analysis of immune-related risk genes associated with sepsis through RNA sequencing and single-cell localization techniques

This study identifies and validates S100A8, S100A9, and S100A12 as significantly upregulated immune-related risk genes in sepsis patients, demonstrating their predominant expression in macrophages and potential involvement in the PI3K-Akt signaling pathway through integrated RNA sequencing, bioinformatics, meta-analysis, and experimental verification.

Hongying Cao, Wei Chen, Peng Tang, Yingchun Hu, Youyu Lan2026-07-29

🧬 biology

Quantum Valence Constants and Structural Stability in DNA: The 10-5-6-5 Numerical Isomorphism as a Biological Ledger

This paper proposes a theoretical framework called "Quantitative Biotheology" that claims a specific numerical sequence (10-5-6-5), derived from valence-bond constants and quantum orbital analysis, represents a divine mathematical constant essential for the thermodynamic stability and structural integrity of DNA.

Carlos Alberto Zuniga Gonzalez2026-07-29

🧬 biology

Phylogenomic and multi-omics analysis of Agarivorans sp. D1326 uncovers an agarolytic pathway involving rare GH118 β‑agarase

This study characterizes the marine bacterium *Agarivorans* sp. D1326 through phylogenomic and multi-omics analyses to elucidate a comprehensive agarolytic network driven by a rare GH118 β-agarase and coordinated extracellular and intracellular enzymatic pathways for efficient agar degradation.

Tao Li, Cong Liu, Chengwei Wu, Boyu Zhang, Ziwei Wang, Yueyue Zhao, Wenbin Gu, Zilin Liu, Fanling Meng, Jingjing Shanggu (…)2026-07-29

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