4401 papers
This study demonstrates that sulforaphane, a natural HDAC inhibitor produced by cruciferous plants, alters chromatin accessibility and reprograms gene expression in herbivorous insects, causing developmental delays and inducing intergenerational epigenetic effects in offspring that were never directly exposed to the compound.
This study demonstrates that the antipsychotics chlorpromazine and clozapine, but not amisulpride, directly interact with lipid bilayers to inhibit membrane fusion and vesicle exocytosis, suggesting a membrane-dependent mechanism that complements their canonical dopamine D2 receptor antagonism.
This study utilizes a system-level analysis of gene activity in psoriatic skin to identify key inflammatory pathways and regulators, ultimately shortlisting seven plant-derived compounds—particularly protopine and atractylon—as promising multi-target therapeutic candidates for psoriasis that require further experimental validation.
This study demonstrates that a decade of warming and nitrogen addition, interacting with plant provenance, regulates the leaf and stem traits of *Solidago canadensis* primarily through soil available potassium and nitrate nitrogen, revealing the invasive provenance's stronger adaptive capacity under future climate change.
This study integrates transcriptomic and single-cell RNA sequencing analyses to identify shared immune–metabolic dysregulation between coronary heart disease and non-alcoholic fatty liver disease, highlighting five key hub genes (FOXO1, SIK1, IER3, BIRC3, and NUPR1) and altered macrophage-mediated cell communication as critical mechanisms underlying their comorbidity.
Using CRISPR/Cas9 to generate complete POR knockout in human adrenal and kidney cells, this study reveals that while canonical steroidogenesis is blocked, low-level DHEA synthesis persists via alternative routes, and specific disease-associated variants like P228L exhibit distinct, enzyme-selective functional deficits that are best characterized under endogenous regulatory control.
This study demonstrates that published benchmark AUROCs are poor predictors of a protein solubility model's generalization performance on independent distributions, revealing that state-of-the-art deep learning models can underperform simple interpretable baselines when applied outside their specific training domains.
This study demonstrates that the short-chain fatty acid acetate inhibits *Coxiella burnetii* replication through a combination of direct bacteriostatic effects, disruption of the acidic intracellular niche via vacuolar pH elevation and size reduction, and broad reprogramming of host cell transcriptional pathways.
This study demonstrates that repeated-measure NIPT models often exhibit inflated performance due to participant-level data leakage in standard record-level cross-validation, necessitating the adoption of participant-grouped validation to ensure robust generalization before clinical application.
This study systematically benchmarks the transcriptional and functional profiles of various human microglial models, revealing that while iPSC-derived microglia best mimic homeostatic brain states and monocyte-derived cells retain immune-alert signatures, 3D culture conditions can partially shift monocyte-derived cells toward a more tissue-adapted phenotype despite their distinct origins.