4401 papers
This study identifies and validates a five-lncRNA prognostic signature based on basement membrane-related genes for predicting overall survival and immune characteristics in patients with idiopathic pulmonary fibrosis (IPF).
This study proposes a bioevo-cybernetic framework demonstrating that increasing regulatory integration drives biological systems toward multistability and organizational-state transitions through attractor-landscape restructuring, a theoretical principle empirically supported by a monotonic increase in regulatory integration estimates across the evolutionary gradient from prokaryotes to humans.
This study presents a comprehensive computational screen of 1,348 FDA-approved drugs against the AlphaFold2-predicted BACE1 structure, identifying Hepatitis C antivirals, particularly Paritaprevir, as novel and potent candidates for Alzheimer's disease drug repurposing.
This study demonstrates that chronic, low-dose exposure to ultrafine amorphous silica induces persistent cellular stress and pro-fibrotic reprogramming in lung epithelial cells in a particle size- and duration-dependent manner, challenging the assumption that amorphous silica is a safe alternative to crystalline silica.
This study integrates multi-omics and network analyses of lung cancer transcriptomic data to identify four cell-cycle-related hub genes (CDK1, CCNB1, CCNA2, and TOP2A) that exhibit significant genetic alterations, correlate with immune cell infiltration, and serve as robust prognostic biomarkers associated with poor patient survival.
This study demonstrates that BCG revaccination can partially reverse the chronic immune stimulation and exhaustion signatures caused by *Schistosoma mansoni* infection in rural Ugandan adolescents, thereby narrowing the immune disparities observed between rural and urban populations.
This study demonstrates that ALPK2 is upregulated by YAP/TAZ activation in oral squamous cell carcinoma, where it drives cell proliferation through MTA2 and AP-1 signaling pathways, suggesting its potential as a novel therapeutic target.
This study reveals that in cyanobacteria, the dissipation of proton motive force recruits flavodiiron proteins to the thylakoid membrane where they utilize Ferredoxin-1 to reduce oxygen, establishing a self-feedback mechanism that dynamically regulates photosynthetic electron flow.
This paper proposes a hierarchical oscillator-based model that successfully mimics human-like perception and anticipation of complex musical rhythms, demonstrating high synchronization accuracy and biologically plausible beta band neuronal activity.
This study constructs the first spatiotemporal proteomic atlas of *Haematococcus pluvialis* lipid droplets, revealing that stage-specific protein remodeling drives astaxanthin accumulation through a conserved two-step sequestration model that integrates multi-organelle functions for carbon repartitioning and redox homeostasis.