4401 papers
In a controlled human infection study of 48 immune-experienced participants, higher pre-inoculation levels of nasal IgG antibodies against the SARS-CoV-2 spike protein, particularly the receptor-binding domain, were strongly associated with protection against viral shedding.
This paper introduces CoralEye, a decentralized, edge-optimized computer vision framework using a quantized MobileNetV2 model to achieve real-time, 97% accurate thermal stress diagnostics on consumer-grade hardware, thereby addressing the critical delay in manual coral reef monitoring and enabling proactive conservation in bandwidth-constrained regions.
This study demonstrates that streptozotocin-induced hyperglycemia upregulates and promotes the colocalization of Pax6 and Tgf-β1 in the mouse heart, suggesting that this interaction drives fibroblast-to-myofibroblast differentiation and contributes to diabetic cardiac dysfunction.
This study validated six susceptibility loci (UBE2U, CDKN2A, SIRT1, NAV2, ST8SIA2, and TP53) in German uranium miners, demonstrating that radon exposure significantly modifies lung cancer risk through gene-environment interactions, while also identifying a potential arsenic interaction for SOX5.
This study utilizes proteomic analysis to demonstrate that outer membrane vesicles (OMVs) from both toxigenic and nontoxigenic *Bacteroides fragilis* strains induce distinct yet overlapping molecular responses in intestinal cell lines, including cytoskeletal reorganization and immune modulation, suggesting that while both strains contribute to anti-inflammatory effects, the presence of toxins in the toxigenic strain may temporarily delay this response until cellular damage is repaired.
Following a focal M1 lesion in macaques, motor recovery is driven by a large-scale network reorganization characterized by an anterior-to-posterior rewiring of the fronto-parietal circuit, where weakened canonical PMv–AIP connections are compensated by reinforced non-canonical PMv–pVIP pathways to restore grasping function.
This study reveals that *Vibrio vulnificus* strains in the Baltic Sea, comprising a mix of environmental and clinical isolates, have adapted to the cold, brackish environment through positive selection on specific genes like *opsX* and *menC*, while undergoing a genomic trade-off characterized by a drastic reduction in defense system complexity and increased mobile genetic element integration to facilitate human infection.
This study demonstrates that in low-signal gene regulatory network inference benchmarks, the relative performance rankings of methods are highly fragile and significantly altered by choices in candidate edge sets and sample sizes, underscoring the critical need to report evaluation protocols alongside benchmark scores.
This study demonstrates that the ranking of gene regulatory network inference methods is highly sensitive to the choice of reference network, revealing that over half of method comparisons can reverse depending on the biological definition and coverage of the ground truth, thereby arguing that reference selection should be treated as a critical experimental variable rather than a fixed background assumption.
This empirical analysis of the scIB single-cell integration benchmark reveals that while the published ranking is locally stable, the winning method and overall ordering are sensitive to defensible changes in weight priorities and task composition, suggesting that benchmark reports should include sensitivity curves and uncertainty estimates rather than relying solely on a single rank table.