4404 papers
This study identifies a robust eight-gene exosome-related diagnostic signature for prostate cancer using machine learning, with a specific focus on characterizing AKR1B1 as a promising biomarker linked to tumor immunity, metabolism, and potential drug targeting.
This study demonstrates that extracts from Brazilian marine macroalgae (*Amansia multifida*, *Enantiocladia duperreyi*) and microalgae (*Chaetoceros muelleri*, *Thalassiosira pseudonana*) exhibit significant antimicrobial and antioxidant activities with low to moderate toxicity, highlighting their potential as sources of bioactive compounds for bioprospecting.
This study utilizes patient-derived iPSC myogenic progenitor cells to identify intrinsic transcriptomic abnormalities in ME/CFS, revealing downregulated cell cycle and immune pathways alongside upregulated metabolic reprogramming, which led to the identification of 22 potential drug repurposing candidates for further therapeutic validation.
This study demonstrates that breast cancer patients exhibit significantly altered expression levels of lncRNAs H19, SPRY4-IT1, and XIST alongside elevated serum IDO1 and TDO2 concentrations, with specific correlations between these markers suggesting their combined role in immune-metabolic dysregulation and potential utility as biomarkers for disease progression.
This study identifies the miR-195/EIF4E axis as a critical mechanism linking peripheral immune dysfunction to central white matter pathology in schizophrenia by regulating BDNF translation and exerting context-dependent immunomodulatory effects.
This study reveals that WRNIP1 preserves genome stability by interacting with and stabilizing the G-quadruplex helicase FANCJ through an ATM-dependent signaling axis, thereby facilitating the resolution of R-loop-associated G-quadruplex structures.
By integrating multi-modal approaches to map the cellular diversity, connectivity, and developmental trajectory of the vestibular periphery, this study establishes a hierarchical molecular scaffold that links embryonic origin to specific neuronal subtypes and their functional roles in balance and spatial orientation.
This multi-cohort study demonstrates that ultra-processed food consumption is associated with a reproducible and modifiable DNA methylation signature across diverse study designs, implicating key genes involved in endothelial signaling, DNA damage response, neuronal function, and metabolic regulation.
The paper introduces CAPRA, a novel response-anchored model that predicts single-cell transcriptional responses to genetic perturbations by combining control states, gene embeddings, and learned corrections, thereby achieving superior accuracy and interpretability in both single- and double-gene tasks compared to existing methods.
This study presents the first complete assembly and comprehensive comparative analysis of the *Nephelium lappaceum* (rambutan) mitochondrial genome, revealing its structural features, RNA editing patterns, and evolutionary relationships within Sapindaceae to provide a foundational resource for future functional and phylogenetic research.