q-bio papers | Gist.Science

Carbon partitioning through the pentose phosphate pathway regulates behavioral maturation in honeybees via a redox–endocrine axis

This study reveals that Deformed Wing Virus infection in honeybees redirects glucose carbon to the oxidative pentose phosphate pathway to generate NADPH, which fuels juvenile hormone biosynthesis and drives precocious behavioral maturation, thereby establishing a conserved metabolic–redox–endocrine axis linking stress-induced metabolic reprogramming to behavioral outcomes.

YUEHLUNG WU, Yun-Heng Lu, Yao-Kuang Tseng, Wei-Chan Chang2026-07-21

🧬 biology

Large-scale in-silico bacterial cryptochrome/photolyase screening identifies an extremophile radical-pair candidate with expanded flavin–tryptophan wiring

Through a large-scale in-silico screening of over 22,000 bacterial cryptochrome/photolyase proteins, researchers identified a thermophilic candidate, A0A6M1RS91, which possesses an expanded flavin–tryptophan electron-transfer network, making it a promising new target for investigating radical-pair photochemistry and magnetic-field sensitivity.

Georgios Miliotis2026-07-21

🧬 biology

The Fas–FADD–caspase-8 axis is a cancer cell-intrinsic determinant of cytotoxic lymphocyte–mediated killing

This study reveals that the Fas–FADD–caspase-8 axis acts as a critical, cancer cell-intrinsic determinant of susceptibility to cytotoxic lymphocyte-mediated killing through mechanisms that extend beyond the canonical executioner caspase-dependent apoptotic pathway.

Youxian Li, Elise Solli, Shixiong Wang, Qian Wei, Nathaniel Saidu, Kjetil Taskén2026-07-21

🧬 biology

FAM155B driven by BPTF promotes breast cancer progression and paclitaxel resistance via SREBP1-mediated fatty acid metabolic reprogramming

This study reveals that the chromatin remodeler BPTF transcriptionally activates FAM155B, which in turn drives breast cancer progression and paclitaxel resistance by upregulating SREBP1-mediated fatty acid metabolic reprogramming.

Yihong Luo, Sijia Zhang, Weifeng Qu, Xuhui Zhao, Yuan Fang, Jun Gao, Jingyi Wang, Shiguang Yang, Wei Zhu, Zhilong Ai, We (…)2026-07-21

🧬 biology

Standing HA phenotypic breadth shapes H5N1 cross-host potential

This study reconstructs the evolution of hemagglutinin (HA) phenotypic traits across thousands of H5N1 viruses to demonstrate that standing phenotypic breadth, rather than simple stepwise mutations, enables the virus to rapidly diversify and adapt to new hosts like dairy cattle, offering a scalable framework for prioritizing cross-host variants.

Justin Bahl, M H M Mubassir, Sachin Subedi, Tanin Rajamand, Mohamed Bakheet, Ludy Carmola, Sihua Peng, Rajan Kandel, Gup (…)2026-07-21

🧬 biology

CIRBP long isoform suppresses breast cancer metastasis via the translational activation of DCLK1-L and microtubule stabilization

This study reveals that the long isoform of the cold-inducible RNA-binding protein (CIRBP-L) suppresses breast cancer metastasis by directly binding to and enhancing the translation of DCLK1-L mRNA, which subsequently stabilizes microtubules through the inhibition of the GSK3β–HDAC6 axis.

Suntaek Hong, Hye-Youn Kim, Young-Mi Kim, Ye-Jin Park, Soyeon Ryu2026-07-21

🧬 biology

Unstable Species Trees Reveal Fundamental Limits to Phylogenomic Inference

This study demonstrates that extreme instability in species trees across the genome of sagebrush lizards, driven by widespread introgression and geographic barriers, challenges the feasibility of inferring a single evolutionary history and supports recognizing multiple distinct species within the *Sceloporus graciosus* complex.

Christopher Blair, Tomas Flouri, Felipe DE MEDEIROS MAGALHÃES, Lauren Chan, Daniel Mulcahy, Sungsik Kong, Adam Leache2026-07-21

🧬 biology

DRP lyase deficient DNA polymerase beta impairs mitochondrial electron transport chain and compromise mitochondrial DNA integrity

This study demonstrates that the loss of dRP lyase activity in DNA polymerase beta impairs mitochondrial DNA integrity and electron transport chain function by disrupting the ROS-antioxidant axis, leading to metabolic dysregulation and increased oxidative stress.

Dawit Kidane, Aashirwad Shahi, Nyima Kinteh, Shengyuan Zhao2026-07-21

🧬 biology

Deep proteomics profiling of the cell secretome by DeepSec

The paper introduces DeepSec, a robust nanoparticle-based method that selectively depletes bovine serum albumin from cell culture media to overcome dynamic range limitations, thereby enabling deep, quantitative proteomic profiling of the secretome across diverse physiological and pathological models.

Amir Ata Saei, Xueyao Wang, Konstantinos Fragkoulis, Aleksandra Wielento, Sabine Willems, Marie-Stéphanie Aschtgen, Anna (…)2026-07-21

🧬 biology

The Representational Geometry of (Dis)Belief: A Multidimensional Space Organized by Belief Direction and Extremity

This study utilizes naturalistic fMRI and behavioral data to demonstrate that the neural representation of belief is a multidimensional geometry organized primarily by belief directionality and extremity, revealing that certainty increases toward both strong belief and strong disbelief.

Gabriel Braun, Einat Shetreet, Yaara Yeshurun2026-07-21

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