4404 papers
This study demonstrates that causal inference relies on the functional coordination of two dissociable neural systems, where the hippocampus constructs a map of causal relations under the control of the inferior frontal sulcus, which encodes an abstract world model to infer unobserved causal connections.
This study reveals that human heart failure with preserved ejection fraction (HFpEF) is characterized by a distinctive accumulation of diverse lipid species in the myocardium that is not driven by obesity alone, differs significantly from heart failure with reduced ejection fraction (HFrEF), and is not accurately replicated by common preclinical animal models.
This study introduces an Effort-based Delay Discounting paradigm to demonstrate that high cognitive effort significantly attenuates the devaluation of delayed rewards, suggesting that willpower failures stem from a specific breakdown in integrating effort and time costs rather than simple cognitive limitations.
This study demonstrates that using base editing to introduce a premature termination codon specifically in exon 7 of the glutamine synthetase gene creates a complete knockout that yields a high-viability, high-productivity CHO cell line for antibody manufacturing, revealing that the position of the termination codon is a critical determinant of cellular phenotype.
This study reveals that SUMOylation of HSF1 is essential for terminating the proteotoxic stress response by promoting the disassembly of nuclear stress bodies and releasing trapped splicing factors, thereby enabling the timely restoration of normal splicing patterns and cellular homeostasis.
This study analyzes behavioral data from 81 participants to confirm a robust Stroop interference effect, demonstrating significantly slower reaction times and high accuracy in incongruent conditions compared to congruent ones, with a mean interference of 106 ms and a large effect size.
This study identifies ANKRD13D as a novel prognostic biomarker and therapeutic target in colorectal cancer that drives tumor progression by interacting with and stabilizing p-ERK to activate the MAPK signaling pathway.
In early Parkinson's disease, individual variations in working memory-related neural activation are primarily driven by caudate integrity, specifically showing a stronger inverse correlation with iron load than a positive correlation with dopamine transporter density, rather than by overt group-level differences compared to healthy controls.
This study demonstrates that Dlx5-6-dependent GABAergic programs are critical for organizing hypothalamic circuits that regulate systemic metabolism, as their deletion in mice leads to developmental remodeling of AgRP/NPY pathways, altered hormonal responsiveness, and a unique metabolic phenotype characterized by reduced energy expenditure but improved insulin sensitivity.
This study identifies a novel extracellular allosteric pocket in the KV1.3 channel, defined by peripheral residues that enable a unique "non-contact selectivity" mechanism, thereby establishing a distinct chemical space for the rational design of selective immunomodulators.