4404 papers
This study demonstrates that an ultrasound-mediated, enzyme-free passaging system preserves the extracellular matrix and adhesion structures of mesenchymal stromal cells, thereby significantly suppressing procedure-induced extrinsic aging and maintaining cell quality and functionality compared to conventional trypsin-based methods.
This study utilizes phylogenetic and structural analyses of proteobacterial P450s to propose that CYP74 clan proteins are the ancestral lineage of the superfamily, characterized by a conserved nine-amino-acid cysteine pocket feature that was progressively lost during evolution to facilitate aerobic metabolism and redox partner interactions.
This study demonstrates that among adipose tissue, bone marrow, and Wharton's jelly sources, bone marrow-derived mesenchymal stromal cells exhibit superior chondrogenic potential, showing the strongest collagen type II deposition and gene expression when cultured in chondrogenic medium with reduced platelet lysate.
This study demonstrates that chronic oxidative stress in human myometrial cells drives molecular remodeling and genomic alterations, including MED12 mutations, providing mechanistic evidence for a causal role of redox imbalance in the initiation of uterine leiomyomas.
This exploratory study demonstrates that museum-based storytelling is a feasible occupation-based task for assessing neurophysiological engagement in older adult-caregiver dyads, revealing expected alpha power modulation during social interaction despite weak associations with cognitive scores and modest dyadic neural synchrony.
This study demonstrates that the human-specific expansion of Olduvai (DUF1220) protein domains promotes brain evolution and neoteny by dosage-dependently suppressing mitochondrial metabolism, which delays cellular maturation and extends neurogenesis to increase neuron production.
This study identifies the vacuolar MATE transporter DTX39 as the key mediator of high-level indolic glucosinolate accumulation in *Arabidopsis* through a proton-anion exchange mechanism, thereby enhancing the plant's chemical defense system.
This study characterizes the genome of the hedgehog-associated mecC-MRSA CC599 lineage, revealing its zoonotic origin, specific virulence factors, and increasing prevalence in human clinical isolates, which suggests a potential for cross-species transmission.
The Korea Biobank Array v2.0 is a population-optimized genotyping platform developed using East Asian whole-genome sequencing data that bridges the gap between cost-effective genotyping and comprehensive variant coverage, thereby significantly enhancing rare variant detection, imputation accuracy, and precision medicine applications for the Korean population.
This study presents an integrated differentiation strategy that generates both 2D cortical monolayers and 3D organoids from a single iPSC batch to create a versatile, scalable platform for modeling juvenile Huntington's disease, effectively recapitulating key neurodevelopmental and neurodegenerative phenotypes while reducing experimental variability and resource consumption.