4404 papers
This study identifies the tumor-intrinsic factor Ist1 as a critical regulator of immune evasion in pancreatic cancer that restricts IFNγ responsiveness by controlling the membrane stability of the IFNγ receptor, thereby revealing a novel therapeutic target for sensitizing tumors to CD8+ T-cell killing.
This study reveals significant functional heterogeneity among *Anacamptis morio* orchid mycorrhizal fungi isolated from Northern Italy, demonstrating that strain-specific variations in thermal resilience, metabolic profiles, and symbiotic germination capacity suggest a diverse portfolio of symbionts is crucial for orchid performance under varying developmental and environmental conditions.
This study describes five novel *Vogesella* species (*V. denitrificans*, *V. rivulicola*, *V. oligotrophica*, *V. montanilacustris*, and *V. limnetica*) isolated from freshwater environments, characterizing their genomic diversity, phylogenetic relationships, and distinct ecological adaptations related to indigoidine synthesis and nutrient cycling.
This study presents the first nuclear genome assemblies for three African blackfly species using a hybrid sequencing approach, providing a foundational resource to address species delimitation challenges in the *Simulium damnosum* complex and to advance the understanding of genome evolution and adaptation in these vectors of onchocerciasis.
This study demonstrates that SIRT2 promotes spinal cord injury repair by inhibiting ferroptosis through the activation of the p53/Nrf2 pathway, thereby reducing iron overload and lipid peroxidation.
This study utilizes integrated bioinformatics analysis of pancreatic islet transcriptomes to identify GLP1R as a key therapeutic hub gene in Type 2 Diabetes Mellitus and proposes the repurposing of FDA-approved drugs Glimepiride and Linagliptin as high-affinity candidates for further preclinical development.
This study employs a cross-study transcriptomic meta-analysis to identify conserved molecular signatures in *Pseudomonas aeruginosa* biofilms, revealing that antibiotic tolerance is driven by coordinated translational reprogramming, metabolic adaptation, and the activation of tailocin-associated contractile systems.
SEMA is a novel framework that integrates spatial context into pathway enrichment analysis, outperforming existing methods to reveal critical spatially resolved biological insights, such as metabolic activities near tertiary lymphoid structures and fibroblast-mediated immune regulation, across diverse tissue and cancer datasets.
This study reveals that distinct evolutionary forces shape the human genome's short tandem repeat landscape, identifying a subset of conserved non-CG motifs that are specifically enriched in pancreatic beta-cell genes and exhibit altered expression and methylation patterns in type 1 and type 2 diabetes, respectively, suggesting their role as condition-dependent regulatory elements in beta-cell dysfunction.
This systematic review of sixteen studies reveals that unengineered landfill leachate and soil harbor diverse, highly metal-tolerant bacteria with promising bioremediation potential, yet their co-occurrence with antibiotic resistance and pathogenicity presents significant human health risks requiring further validation and standardized assessment.