4404 papers
This study identifies the transcription factor BRN2 as a critical regulator of melanocyte stem cell homeostasis that suppresses stress-induced hair greying by maintaining DNA repair pathways and preventing premature differentiation and senescence.
This study demonstrates that while a sustained-action disinfectant effectively reduces bacterial viability in hospital greywater systems, its antibacterial performance varies significantly by pipe material, with rigid PVC showing the greatest efficacy and flexible PVC exhibiting the highest bacterial persistence and residual biofilm structures.
This study reveals that anthropogenic disturbance interacts with insect developmental modes to shape plant-herbivore network structure in Brazilian savannas, where holometabolous insects exhibit high specialization and urban-driven functional decoupling, while hemimetabolous insects maintain modular, low-connectance networks with reduced specialization in urban areas.
This study reveals that the loss of fragile X mental retardation protein (FMRP) in Parkinson's disease leads to upregulation of insulin-degrading enzyme (IDE), which normally suppresses α-synuclein aggregation, thereby identifying a novel FMRP-IDE axis that modulates early pathogenic events in Parkinson's disease.
This study demonstrates that ligand binding drives ACKR3 to form nanoclusters on T cells, which actively organize CXCR4 into heterocomplexes to attenuate CXCR4-mediated Gαi signaling, revealing a novel mechanism by which ACKR3 fine-tunes chemokine responses beyond its role as a scavenger.
This study uses an epidemiological model to demonstrate that while sub-optimal response of Onchocerca volvulus to ivermectin can hinder elimination even with biannual mass drug administration in hyperendemic regions, switching to moxidectin offers a viable path to achieving transmission elimination.
This study utilizes COI DNA barcoding on 508 marine fish specimens from the East Coast EEZ of Peninsular Malaysia to reveal 225 species, identify three new regional records, and uncover cryptic diversity within five species, thereby establishing a comprehensive reference library to support biodiversity assessment and conservation in the South China Sea.
This study demonstrates a host-informed engineering strategy in *Komagataella phaffii* that combines CRISPR-Cas9 genome editing with transcriptomic analysis to overcome synthetic lethality and growth defects, thereby enabling the production of human biantennary N-linked glycans.
By investigating community assembly mechanisms across multiple spatial scales in a primary Hainan Island rainforest, researchers developed a scale-dependent restoration strategy that successfully transformed 400 hectares of aged rubber plantations into a high-diversity tropical forest dominated by native species, offering an effective framework for global rainforest restoration and climate change mitigation.
This study utilizes a closed-loop core-conductor model with realistic nociceptor kinetics to demonstrate that single-fiber ephaptic crosstalk is insufficient to explain dynamic mechanical allodynia, whereas multi-fiber spatial summation emerges as a plausible mechanism capable of generating significant subthreshold depolarization.