4404 papers
A 12-week French Contrast Training program was found to be more effective than traditional resistance training in enhancing lower-limb explosive performance metrics, including jump height, reactive strength, sprint speed, and peak force, among male collegiate basketball players.
This study utilizes synchronized proteomic and phosphoproteomic profiling of APP/PS1/MAPT mice to demonstrate that the retina exhibits earlier and broader Alzheimer's-related molecular alterations than the hippocampus, revealing distinct tissue-specific pathways and shared dysregulated molecules that support the retina as a noninvasive window into early brain pathology.
This study reveals that the periodic formation of the vaginal closure membrane in guinea pigs is a hormone-regulated tissue remodeling process driven by a unique population of pluripotent stem cells residing in a hairless epidermal transition zone at the vaginal orifice.
This study characterizes a novel de novo DNM1L mutation (p.Arg365Gly) in a pediatric patient with epileptic encephalopathy, demonstrating that the variant disrupts DRP1 oligomerization, leading to defective mitochondrial fission, widespread neurodegeneration, and refractory seizures.
This study utilizes population viability analysis to demonstrate that eradicating a free-ranging dog population in Japan requires the sustained annual capture of 45 adult dogs, as adult survival is the primary driver of population growth and must be targeted alongside the reduction of anthropogenic food resources.
This exploratory cross-sectional study of 98 children aged 9 to 10 found that 20 m sprint time was the most consistent predictor of 505 change of direction performance, with back leg strength further explaining variance in boys and visual reaction time in girls, though the resulting models require further validation before clinical or individual use.
This study analyzes data from over 83,000 Chinese college students from 2013 to 2025 to demonstrate that physical fitness indicators are strongly associated with Body Mass Index and that an XGBoost machine learning model can effectively predict BMI, with pull-ups, vital capacity, and long-distance running identified as key predictive features.
By developing the TrioMix-UPD framework and applying it to 3,740 congenital heart disease trios, researchers revealed that uniparental disomy is a significantly enriched and underrecognized genetic cause of the disease, uncovering novel pathogenic variants and candidate genes while linking the condition to meiotic segregation defects and imprinting dysregulation.
This study demonstrates that while both Dihydromyricetin and Silybin partially protect middle-aged mice from alcohol-associated liver injury, they achieve this through distinct gut–liver axis adaptations involving divergent metabolic, epithelial, and microbial remodeling mechanisms, thereby highlighting the critical need for age-stratified intervention strategies.
This study presents the first complete assembly and comprehensive characterization of the *Averrhoa carambola* mitochondrial genome, revealing its structural features, repetitive elements, and evolutionary relationships within the order Oxalidales to establish a foundational resource for future phylogenetic and breeding applications.