4404 papers
This study demonstrates that short, 10-second video clips of affiliative conspecific social interactions serve as robust alternative reinforcers capable of maintaining operant responding in rhesus monkeys, offering a viable non-ingestive method for behavioral research.
This study demonstrates that exosomes derived from CD271+ umbilical cord mesenchymal stem cells promote angiogenesis in endometriosis by delivering miR-124-3p, which directly targets and suppresses PGF to enhance endothelial cell migration and tube formation.
In a longitudinal study of Gambian children, *Prevotella stercorea* is shown to protect against acute respiratory infections through a species-autonomous, host-context-dependent pathway that operates independently of overall gut microbiome richness, with its protective effects and immune interactions varying significantly based on the child's nutritional status (WAZ).
This study establishes a systematic framework for analyzing A-to-I RNA editing in single-cell transcriptomes by benchmarking diverse methods across over 1.1 million cells, identifying BCFtools with strand annotation as the optimal pipeline, and demonstrating how these tools reveal cell-type-specific editing dynamics reshaped by disease contexts like Down syndrome and cancer.
This study retrospectively analyzed nine Nemaline Myopathy patients using whole-exome sequencing and bioinformatics to identify pathogenic variants in *TPM3*, *NEB*, and *ACTA1* genes, demonstrating how thermodynamic stability analysis of *NEB* missense variants can enhance diagnosis, prognosis, and genetic counseling for this genetically heterogeneous disorder.
By leveraging long-read sequencing and the human pangenome, this study demonstrates that Z-DNA-forming sequences are highly constrained, enriched in previously unresolved repetitive regions, and act as significant drivers of genomic instability through an excess of small insertions, deletions, and complex structural variants.
By utilizing cryofixation to preserve overwintering honey bee colonies in a near-native state, this study reveals that the multi-scale distribution of *Varroa destructor* is structured by nested spatial filters ranging from colony-level zones and frame positions to specific abdominal attachment sites on individual bees.
This study demonstrates that classical machine learning models trained on matched gene sets consistently match or outperform scGPT-based pipelines in both accuracy and statistical calibration for cell-type annotation across six large-scale single-cell atlases, challenging the assumed superiority of single-cell large language models without rigorous matched baselines.
This longitudinal study of kindergarten beginners reveals that the transition to school is associated with increased infection burden and a delayed restructuring of the gut microbiome, characterized by a shift toward Proteobacteria dominance and the depletion of *Bacteroides fragilis*, which correlates with higher symptom severity.
This study reveals that DHCR24 deficiency accelerates endothelial senescence by disrupting the SPHK2/SPNS2-S1P axis, which reduces intracellular sphingosine-1-phosphate levels and impairs nitric oxide production, thereby establishing a critical metabolic link between DHCR24 and vascular aging.