🧬 Category

q-bio

4404 papers

🧬 biology

Extremophilic Adaptations Across the Archaeal Domain Are Governed by Lineage Clustering

This study demonstrates that apparent incompatibilities between archaeal extremophilic traits, such as halophily and methanogenesis, are primarily artifacts of lineage clustering and phylogenetic pseudoreplication rather than intrinsic biochemical constraints, as evidenced by the frequent co-occurrence of these adaptations in non-Halobacteria lineages when analyzed using phylogenetically corrected methods.

Ajay Vellanki2026-07-21
🧬 biology

GPCR mechanical pivots are packed closer to the membrane center than pivots in other polytopic membrane protein folds

This study demonstrates that the mechanical pivots of G protein-coupled receptors (GPCRs), defined by tightest local atomic packing, are significantly closer to the membrane center than those of other polytopic membrane protein folds, indicating that this central positioning is a distinctive feature of the GPCR superfamily rather than a universal property of transmembrane bundles.

Huazhang Shen2026-07-21
🧬 biology

Differentiable subset binding: gradient-based cross-view itemset mining for heterogeneous data

This paper introduces Differentiable Subset Binding (DSB), a scalable, gradient-based method that overcomes the combinatorial limitations of traditional Apriori-based subset binding to efficiently identify maximal co-occurring itemsets across heterogeneous data views, outperforming existing baselines in both synthetic benchmarks and real-world biological applications.

Yayoi Natsume-Kitatani2026-07-21
🧬 biology

Automatic clustering of self-defined groups to minimize false disease associations and maximize within-group genetic similarity

The paper introduces HAPLOCLUST, a size-constrained, population-level clustering method that groups individuals based on HLA genetic similarity to minimize false disease associations and maximize within-group homogeneity, offering a robust alternative to self-reported ethnic classifications for improving transplant matching and genetic studies.

Sapir Israeli, Martin Maiers, Sigal Manor, Bracha Zisser, Yoram Louzoun2026-07-21
🧬 biology

Generating and navigating single cell dynamics via a geodesic bridge between nonlinear transcriptional and linear latent manifolds

GeoBridge is a novel framework that models cellular dynamics as geodesic trajectories within a learned Riemannian metric space to enable the reconstruction of continuous, noise-robust transcriptional programs and the controlled navigation between distinct cell states from sparse, unpaired single-cell RNA sequencing data.

Luonan Chen, Junchao Zhu, Zhenyi Zhang, Yuhao Sun, Hao Dai, Wen Han, Peijie Zhou2026-07-21
🧬 biology

Sex-Specific Exploration Patterns and Noradrenergic Modulation in Object Recognition Memory: Role of the Perirhinal Cortex

This study demonstrates that noradrenergic modulation of object recognition memory via β2-adrenergic receptors in the perirhinal cortex facilitates memory formation in female mice through familiarity-based mechanisms, whereas males exhibit distinct, stimulus-dependent responses, highlighting critical sex differences in the neural basis of memory.

Lorena Roselló-Jiménez, Raúl Pastor, Marta Miquel, Laura Font2026-07-21