4404 papers
This paper proposes a Soft Actor-Critic reinforcement learning framework integrated with a behaviorally heterogeneous S1S2IR epidemic model to dynamically optimize intervention strategies, demonstrating through COVID-19 calibration that it effectively reduces infection peaks and costs compared to static policies.
This paper proposes a wastewater surveillance method that utilizes epigenetic markers, such as DNA methylation, to monitor community-wide physiological states and public health trends by analyzing how environmental and lifestyle factors influence gene expression without altering the DNA sequence.
This paper documents a previously unreported stereotyped four-stroke scratching sequence in domestic chickens and proposes a four-tier neuro-behavioral model attributing this evolutionarily optimized foraging pattern to spinal, brainstem, and cerebellar-basal ganglia mechanisms rather than cortical cognition.
This study analyzes the TIHM home-monitoring cohort to demonstrate that pre-agitation disruption in dementia is characterized by a distinct "entropy anatomy" where irregularity metrics (sample and approximate entropy) significantly increase while long-range persistence (Hurst exponent) decreases, supporting the use of multi-feature sequences over single-metric triggers for detection.
This study leverages sex- and ancestry-stratified rare-variant gene-burden analyses across multiple cardiometabolic disorders to expand the catalog of causal gene–phenotype associations from 368 to 534, revealing that approximately one in six individuals carries risk-increasing alleles while one in nine carries protective ones.
This study demonstrates that inhibiting TAM kinase receptors in leukemia cells modulates the Axin-2/BCL2 axis to regulate intrinsic mitochondrial apoptosis, suggesting that targeting this pathway could overcome treatment resistance in chronic myeloid and acute lymphoid leukemia.
This paper proposes a comprehensive a posteriori diagnostic framework that moves beyond simple residual loss to evaluate the reliability of Physics-Informed Neural Networks for option pricing by analyzing residual-error geometry, Greek stability, and no-arbitrage constraints, demonstrating through extensive benchmarks that these structural diagnostics provide a more accurate assessment of pricing errors than residual metrics alone.
This study establishes that optimal urinary cell-free DNA preservation requires processing urine into supernatant with 10 mM EDTA, followed by storage at -80°C for long-term stability or at room temperature for up to 7 days, while avoiding high EDTA concentrations, uncentrifuged whole urine, and post-thaw secondary centrifugation.
In early-stage melanoma, CD8+ T cells adopt a tissue-resident memory-like phenotype to establish initial immunosurveillance, but their cytotoxic and sentinel functions are critically suppressed by co-localizing regulatory T cells, representing a key mechanism of tumor immune evasion.
This study establishes a sequence-encoded molecular grammar for intrinsically disordered protein regions that predicts and enables environmental sensitivity to hyperosmotic stress, demonstrating that specific patterning of oppositely charged residues is both necessary and sufficient for high responsiveness and offering design principles for engineering synthetic protein sensors.