🧬 Category

q-bio

4404 papers

🧬 biology

Distinctive properties of the prion protein in the brain and retina in the amyloidosis associated with the PRNP F198S Mutation. *

This study provides the first comparative neuropathologic and biochemical analysis of PrP deposits in the brain and retina of individuals with GSS-associated F198S mutation, revealing that while both tissues contain seeding-capable aggregates, the retina lacks the constitutive 8 kDa proteolytic fragments found in the brain and exhibits distinct amyloid and glycosylation properties.

Bernardino Ghetti, Bradley S. Glazier, Michele Fiorini, Kathy L. Newell, José M. Bonnin, Jill R. Murrell, Leah Rie Varne (…)2026-07-16
🧬 biology

Defining the Role of Progesterone Signaling in High-Grade Serous Ovarian Cancer Using Fallopian Tube Models

Using fallopian tube-derived tumorigenic models, this study demonstrates that progesterone signaling inhibits the migration and adhesion of early-stage high-grade serous ovarian cancer cells while downregulating angiogenesis and stemness markers, though this protective effect is lost in cells harboring additional oncogenic drivers like mutant p53.

Diandra M. Vaval Taylor, Jason A. Guerrero, Tova M. Bergsten, Katherine E. Schoenhardt, Angela Russo, Daniel D. Lantvit (…)2026-07-16
🧬 biology

Effects of human umbilical cord mesenchymal stem cell (hUC-MSC)-derived exosomes on HIBD immunoinflammation in neonatal rats

This study demonstrates that human umbilical cord mesenchymal stem cell-derived exosomes alleviate neuroinflammation and improve spatial memory in neonatal rats with hypoxic-ischemic brain damage by delivering miRNA-146a-5p to suppress the IRAK/TRAF6 signaling pathway, thereby shifting microglia from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype.

Xiaoyun Xiong, Ziyu Luo, Juan Chen2026-07-16
🧬 biology

Direct Differentiation of Human Pancreatic Islet-Derived Mesenchymal Stromal Cells into Glucose-Responsive Insulin-Producing Cells

This study demonstrates that human pancreatic islet-derived mesenchymal stromal cells can be rapidly and efficiently reprogrammed into functional, glucose-responsive insulin-producing cells using a sequential viral delivery of ISP (PAX6, ISL1, REST1/2 knockdown) and PMN (PDX1, NGN3, MAFA) transcription factors, establishing them as a promising source for cell-based diabetes therapies.

Nour Ebrahim, Nikolay Kondratyev, Alexander Artyuhov, Alexei Timofeev, Aleksei Stepanenko, Erdem Dashinimaev2026-07-16
🧬 biology

Regionally-explicit integrated population models developed for a migratory bird suggest biased demography, masking broader inference capacity

This study demonstrates that regionally explicit integrated population models for mourning doves in Missouri reveal how biased, non-representative sampling schemes can significantly underestimate survival rates and mislead demographic inferences, highlighting the critical need for practitioners to test and correct for such biases in wildlife monitoring.

Elisa Constancia Elizondo, Thomas W Bonnot, Thomas R Thompson, Mitch D Weegman2026-07-16
🧬 biology

RAcolony: A Multimodal Platform Integrating Raman Spectroscopy and Automated Imaging for Efficient Construction of Personalized Gut Microbiome Biobanks

The authors present RAcolony, an intelligent, high-throughput platform that integrates Raman spectroscopy with automated imaging to efficiently construct personalized gut microbiome biobanks by significantly reducing redundancy and capturing high-resolution microbial diversity, including novel taxa.

Yang Yan, He Jiang, Jian-Bo Ma, Min-Zhi Jiang, Chen Chen, Zi-Nuo An, Xin-Yao Li, Guozhong Chen, Xiao-Yang Zhu, Tian-Yu L (…)2026-07-16✓ Author reviewed ⓘ
🧬 biology

Which external symptoms predict impaired welfare in aged mice? Validation of a live scoring system against necropsy findings

This study validates a live scoring system for aged mice by demonstrating that specific external symptoms, such as abdominal masses and severe neurological issues, strongly predict internal disease burden and tumor presence, thereby providing a standardized framework for objective humane endpoint decisions.

Birte von der Beck, Gero Hilken, Felix Braczko, Philip Dammann2026-07-16
🧬 biology

Tumor Perfusion Shows Substantial Hour-Scale Temporal and Spatial Dynamics in Superresolution Ultrasound Measurements

Using superresolution ultrasound localization microscopy, this study reveals that tumor perfusion exhibits significant spatial heterogeneity and temporal instability on an hour-scale, suggesting that short-term fluctuations in microvascular dynamics may critically impact drug delivery efficiency and treatment response variability.

Alexandra Raab, Jasmin Baier, Céline Porte, Thomas Lisson, Palma Emese Inczeffy, Rahaf Mihyar, Andreas Schuppert, Renée (…)2026-07-16
🧬 biology

Precipitation frequency and predictability interactively affect lizard life-history traits in absence of water shortage

This study demonstrates that even in the absence of water shortage, the interactive effects of altered precipitation frequency and predictability significantly influence the body size, growth, and survival of the common lizard (*Zootoca vivipara*), thereby affecting population demography and highlighting the need to consider combined climatic factors when predicting climate change impacts.

Rebeca Vicente Moreno, Patrick S. Fitze2026-07-16