4404 papers
This study characterizes the genomic landscape of inherited retinal diseases in Argentina by analyzing 808 molecularly solved patients from the SARA cohort, revealing a complex architecture of recurrent and rare variants across 109 genes that informs patient stratification for clinical trials and gene therapies.
This study demonstrates that PDGFRβ signaling is essential for orchestrating meningeal repair in zebrafish by mobilizing arachnoid cells from specific sulci to injury sites, a process that subsequently facilitates neurite regrowth and macrophage recruitment, offering potential therapeutic insights for overcoming CNS regeneration barriers in mammals.
This paper introduces Cyclome930, a comprehensive resource of 930 cyclic peptides featuring a novel symmetry-aware alignment algorithm and exhaustive molecular dynamics simulations, which collectively enable the development of machine learning models to predict thermal stability and critical metal-binding likelihood for computational peptide design.
This study introduces an accessible, recirculating organ-on-a-chip model that mimics pregnancy-associated breast cancer by coupling breast cancer and trophoblast cells to reveal how flow-driven cross-talk induces ER stress, thereby driving tumor invasion and placental dysfunction while offering a platform for therapeutic screening.
This paper reinterprets the Synaptic Homeostasis Hypothesis by distinguishing reversible synaptic downscaling (P1) from glymphatic waste clearance (P2), proposing that NREM sleep induces a metastable state where spine fate depends on the efficacy of metabolic waste removal rather than immediate deletion.
This study supports a dynamic model of social information processing in autism, demonstrating that autistic children exhibit early heightened physiological and neural responses to social stimuli followed by a rapid, time-dependent regulatory mechanism that subsequently attenuates the behavioral impact of these representations.
This study demonstrates that HOXC10 promotes thyroid cancer metastasis by directly activating CCL2 transcription, which drives M2 macrophage polarization and tumor microenvironment remodeling, thereby identifying HOXC10 inhibition as a potential therapeutic strategy.
This study reveals that microplastics released from disposable food packaging, specifically PET, induce gut barrier dysfunction and liver injury in rats by disrupting the gut-liver axis and inhibiting the Keap1-Nrf2 pathway, thereby triggering oxidative stress and ferroptosis.
This study reveals that LPS-induced intestinal epithelial damage disrupts MUC2 O-GalNAcylation and adherens junction integrity, but GalNT3 overexpression restores long-chain O-glycans on MUC2, stabilizing E-cadherin and calcium homeostasis to repair the mucosal barrier and mitigate LPS translocation.
This study proposes that Alzheimer's disease lysosomal dysfunction stems not from structural pump failure but from an "energy-starved lysosome" state caused by the disruption of the astrocyte–neuron lactate shuttle, where declining astrocytic lactate export (MCT4) creates a cross-cellular energy deficit that impairs neuronal V-ATPase activity despite preserved pump abundance.