4404 papers
This study demonstrates that TGM2 promotes the intracellular persistence of *Staphylococcus aureus* in bovine mammary epithelial cells by upregulating its expression to aggravate xenophagy dysfunction and impair lysosomal clearance of the pathogen.
This study presents a novel, disposable paper-based electrochemical biosensor utilizing carbon dots and a liposome–biorecognition complex to sensitively and selectively detect anti-SARS-CoV-2 spike protein antibodies in real nasopharyngeal samples, offering a promising point-of-care solution for monitoring immunity without specialized laboratory facilities.
This study utilized RNA sequencing to demonstrate that four histone deacetylase inhibitors elicit distinct, cell type-dependent transcriptomic responses in feline kidney and astrocyte cell lines, providing a foundational resource for developing HDAC inhibitor-based therapies for domestic cats.
This multi-omics study integrates transcriptomic data and machine learning to identify neuroinflammation-related genes and exosomal miRNAs, establishing a robust five-gene diagnostic signature (PTGDS, RTN3, MAG, PROK2, and CNTNAP2) and elucidating monocyte-driven neuroinflammatory mechanisms in Parkinson's disease.
This paper introduces a Bayesian sparse mixed-response species distribution model that integrates shared environmental feature selection, Polya-Gamma augmentation, and low-rank spatial dependence to effectively handle continuous, binary, and count ecological data while outperforming response-wise regressions in recovering sparse structures and improving predictive accuracy.
This paper introduces a scalable penalized regression framework comprising Spike-and-Slab Lassosum (SSL) and its prior-informed extension (pSSL), which significantly enhance both the predictive accuracy and computational efficiency of single- and cross-ancestry polygenic scores while addressing Eurocentric biases in genomic studies.
This study demonstrates that overexpressing the foxtail millet gene SiGAD1, particularly its full-length variant, significantly enhances glutamate decarboxylase activity to substantially increase GABA accumulation and reduce glutamate levels in grains, offering a promising strategy for breeding high-GABA millet varieties.
This study identifies distinct genetic resistance mechanisms in wheat against the necrotrophic pathogens *Parastagonospora nodorum* and *Pyrenophora tritici-repentis*, revealing a major QTL for tan spot resistance on chromosome 1B, multiple minor QTLs for Septoria nodorum blotch, and differential cytological defense responses that highlight the unique underlying strategies for combating each disease.
This study reveals that the PI4P phosphatase SAC7 dynamically regulates ER-PM contact sites by removing SYT1 tethers at the growing tip of root hairs, thereby linking PI4P signaling to the control of polarized cell growth in plants.
This study presents the first length–weight relationship and growth pattern data for eleven marine finfish species landed at the Thondi fish market in Palk Bay, India, revealing that most species exhibit negative allometric growth with varying degrees of correlation between total length and weight.