4404 papers
Genomic and structural analyses of the 2026 Bundibugyo virus outbreak suggest that while the mAb114 therapy may be compromised by specific mutations, the MBP134 cocktail remains a promising broadly protective option and the Inmazeb trimeric cocktail retains efficacy through synergistic binding, highlighting the critical need for urgent experimental validation.
This paper introduces SegDAFormer, a novel dual-head transformer architecture that unifies dopaminergic neuron segmentation and Tyrosine Hydroxylase (TH) phenotypic quantification in Parkinson's disease models, significantly outperforming existing methods by providing a scalable, biologically interpretable framework for automated histological assessment.
A data-validated mathematical model demonstrates that baloxavir achieves more rapid influenza viral load elimination than oseltamivir by inhibiting viral replication earlier in the cycle, suggesting that viral load reduction kinetics are drug-class specific and may require independent validation as clinical surrogate endpoints.
This study describes three new species of *Isospora* (*I. cantoris*, *I. melodiae*, and *I. villai*) infecting the song sparrow (*Melospiza melodia*) in the Toluca Valley, Mexico, based on the morphological characteristics of their sporulated oöcysts.
This paper presents a dimensionally consistent fractional-order delayed predator-prey model incorporating fear, refuge, Holling type-III response, and nonlinear harvesting to analyze how fractional memory and time delay jointly govern stability switching and ecological thresholds, validated through comprehensive analytical and numerical investigations.
This study provides the first evidence that anuran distress calls function to increase escape opportunities by attracting secondary predators, such as marmosets, to interfere with snake attacks rather than by startling the primary predator or warning conspecifics.
This study reveals that the protective APOE3 Christchurch variant mitigates lipid-driven neuroinflammation in autosomal dominant Alzheimer's disease by promoting sphingolipid recycling and glial lipid remodeling while suppressing de novo cholesterol biosynthesis.
This study identifies two principal NAD+-dependent aldehyde dehydrogenases (LPH33_RS08240 and LPH33_RS17900) in *Rhodococcus* sp. RDE2 responsible for oxidizing oligo-isoprene aldehydes during natural rubber degradation, while also revealing the involvement of additional ALDHs in NADP+-dependent activity.
This study reports the genomic characterization of a novel bunyavirus, Fusarium solani bunya virus 2 (FsBV2), identified in the phytopathogenic fungus *Fusarium solani*, which possesses a three-segment genome encoding an RdRp, a YwqJ-like deaminase, and a flavoprotein, and is proposed as a new member of the class *Bunyaviricetes*.
This paper introduces Bio-homeostasis Information Theory (BIT), a resource-constrained statistical framework that unifies diverse dynamical systems by defining the "bifurcation information rate" as a necessary condition to determine if available resources are sufficient to maintain a system's statistical pattern against accumulating disturbances.