4404 papers
This study identifies conserved, interval-specific tRNA-like motifs derived from HIV-1 and HIV-2 within human introns of key genes, proposing that these genomic fossils may regulate host splicing by physically interfering with spliceosome assembly through interactions with viral RNA structures.
This paper proposes and validates a computational model based on residual membrane depolarization to explain associative learning-like behavior in the unicellular protozoan *Stentor coeruleus*, demonstrating that such complex behavior can arise from plausible non-synaptic cellular mechanisms.
This study demonstrates that hydrolyzed sponge spicules derived from *Haliclona* sp. function as natural biogenic microneedles that significantly enhance transdermal drug delivery by creating microchannels and reversibly disrupting stratum corneum lipid organization and tight junction proteins, outperforming commercial silicon microneedles for macromolecular and hydrophobic drugs while maintaining biocompatibility.
This study establishes a genomic reference for a closed SPF Beagle colony through whole-genome and reduced-representation sequencing, confirming its genetic stability and suitability for toxicology studies while highlighting the importance of accounting for family structure in experimental design to ensure reproducibility.
This study demonstrates that a widely accepted molecular subtyping pipeline for postmortem psychiatric brains fails to detect reproducible disease-specific patterns because it is systematically confounded by brain region rather than diagnosis, highlighting the critical need for explicit confound testing in transcriptomic analyses.
This study identifies *Chromobacterium violaceum* as a biofilm-forming, potentially virulent bacterium harboring specific resistance and virulence genes (*papC*, *afaCc*, and *rmpA*) isolated from water distribution systems in Choba, Rivers State, Nigeria, underscoring the public health risks posed by such pathogens in treated water supplies.
This study analyzes lung microbial communities in HIV-positive and HIV-negative patients, revealing that fungal diversity is significantly elevated in GM-positive individuals while bacterial diversity remains stable, and highlights the critical inverse relationship between viral load and CD4+ T cell counts to underscore the necessity of monitoring immune status and microbial equilibrium in HIV management.
This study identifies and functionally validates two novel compound-heterozygous *PYCR1* variants as pathogenic causes of autosomal-recessive cutis laxa, expanding the mutation spectrum and characterizing the associated neurodevelopmental phenotype through integrated genetic, functional, and multi-omics analyses.
This study demonstrates that specific, timely chemogenetic activation of the hypothalamic paraventricular nucleus inhibits cervical cancer progression by downregulating immune-related genes and curbing neutrophil infiltration through a newly identified brain-body axis.
This study demonstrates that myelin repair following focal demyelination is a spatially heterogeneous process shaped by distinct regional microenvironmental factors and cellular dynamics in the hippocampal fimbria and lateral olfactory tract, highlighting the need for region-tailored therapeutic strategies to enhance remyelination.