🧬 Category

q-bio

4404 papers

🧬 biology

ionScell enables microscopy-independent single-cell spectral extraction from MALDI mass spectrometry imaging.

The paper introduces ionScell, an open-source Python pipeline that enables reliable, microscopy-independent single-cell spectral extraction from MALDI mass spectrometry imaging by deriving cell boundaries directly from Total Ion Current images, thereby achieving high-accuracy cell classification and revealing molecular heterogeneity without the need for co-registered microscopy or manual annotation.

Michel Salzet, Laurine Lagache, Yanis Zirem, Lea Ledoux, Julie Defrance, isabelle Fournier2026-07-15
🧬 biology

Gut Microbiota-Derived Indole-3-Acetic Acid Induces PCOS by Disrupting Granulosa Cell Function under Metabolic Stress

This study reveals that under metabolic stress, the gut microbiota-derived metabolite indole-3-acetic acid (IAA), which is enriched by *Bacteroides fragilis* in PCOS patients, disrupts granulosa cell function and induces PCOS-like phenotypes by activating the aryl hydrocarbon receptor (AHR) signaling pathway.

Yan Wang, Zhijian Luo, Ting Yang, Xiaorong Luo, Xuehong Zhang2026-07-15
🧬 biology

A Novel Ferro-Aging-Related Gene Signature for Prognosis and Targeted Drug Prediction in Cervical Cancer

This study establishes a novel eight-gene ferro-aging-related signature that serves as a robust prognostic indicator for cervical cancer, elucidates its association with an immunosuppressive tumor microenvironment and specific cell dynamics, and identifies potential therapeutic compounds through integrated multi-omics and AI-driven drug screening.

Zhengchao Yan, Sijuan Tang, Naqiu Yin, Ying Wan, Yufei Pan, Yue Li, Ximei Huang, Liwu Zhang, Jianlin Chen2026-07-15
🧬 biology

Forest degradation reshapes trophic functioning in vertebrate food webs across Amazonian forests

This study reveals that forest degradation in the Amazon, even at relatively low disturbance levels, significantly alters vertebrate food web functioning by increasing carnivory and decreasing herbivory through shifts in species composition and biomass, demonstrating that energetic metrics are more sensitive indicators of ecosystem disruption than traditional biodiversity measures alone.

Ana Carolina Antunes, Ulrich Brose, Anelise Montanarin, Benjamin Rosenbaum, Carlos Peres, Carsten Meyer, Henrique Pereir (…)2026-07-14
🧬 biology

Multi-generational exposure to glyphosate and glyphosate-based herbicides induces neurobehavioral alterations in Sprague-Dawley rats

This study demonstrates that multi-generational exposure to glyphosate and glyphosate-based herbicides at doses currently considered safe induces significant neurobehavioral impairments, including increased anxiety and motor deficits, in Sprague-Dawley rats, with formulation additives and male sex exacerbating these adverse effects.

I. Menghetti, I. Thiara, S. Panzacchi, L. Falcioni, R. Giovannini, M. Iuliani, M. Manservigi, S. Nanni, D. Sgargi, V. St (…)2026-07-14
🧬 biology

Integrative Multi-Omics and Single-Cell Analyses Reveal that Polyamine Metabolic Reprogramming Shapes an Immunosuppressive Microenvironment and Identifies ZWINT as a Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma

This study integrates multi-omics and single-cell analyses to demonstrate that polyamine metabolic reprogramming in myeloid cells drives an immunosuppressive microenvironment in lung adenocarcinoma, leading to the identification of the transcriptional regulator ZWINT as a robust prognostic biomarker and therapeutic target.

Hui Zou, Yiwei Fan, Qinting Fan, Xiaotian Liu, Weiguo Jin, Shichun Lu, Qianhe Ren2026-07-14
🧬 biology

Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptides

This study employs an unbiased approach to identify disease-associated T-cell receptors in type 1 diabetes, linking them to convergent HLA-restricted clusters and revealing their specific targets as hybrid insulin peptides, thereby establishing these receptors as potential biomarkers and clarifying the role of effector T cells in disease pathogenesis.

Rebecca Elyanow, Amanda Moore, Tim Hayes, Enrique Crespo, Erica Gumucio, Melanie Laur, Sami Rantisi, Ninnia Lescano, Bra (…)2026-07-14
🧬 biology

Angiogenic and Immunomodulatory Effects of Hydroxyapatite Nanoparticles: A Promising Nanoplatform for Cutaneous Tissue Regeneratio

This study demonstrates that synthesized hydroxyapatite nanoparticles (10–25 nm) are biocompatible and promote cutaneous tissue regeneration by enhancing cell migration and modulating the expression of key angiogenic and immunomodulatory genes (VEGF, FGF, IL-4, and IL-1β) in vitro.

Deena Mol Jesudhasan, Kalaimathi Janakiraman, Rajeshkumar Shanmugam2026-07-14