4404 papers
This study investigated 670 Taiwanese high school students and found that specific single nucleotide polymorphisms (SNPs) in GABA-related genes (GABRA4, GABRG2, GABBR1, and GABRQ) are significantly associated with variations in diverse cognitive abilities, suggesting a genetic basis for individual learning differences that could inform personalized education strategies.
AIVA is an agentic platform that integrates phenotype-aware prioritization and evidence-grounded ACMG/AMP classification to outperform existing tools in rare disease diagnosis by automating literature review, applying gene-specific rules, and self-correcting input errors.
This study reveals that the Parkinson's disease-associated LRRK2-G2019S mutation exacerbates metabolic stress-induced neurodegeneration by stabilizing p21 via a kinase-independent interaction with DDB1 to drive astrocytic senescence, a pathological process that can be reversed by LED-based photobiomodulation.
This study demonstrates that activating NRF2 to restore lipophagy, rather than inhibiting lipid droplet biogenesis, resolves lipid accumulation in microglia, thereby rewiring their immunometabolism to reduce neuroinflammation and promote neuronal survival following spinal cord injury.
The paper introduces quantmsdiann, a scalable, open-source Nextflow workflow that standardizes and accelerates the reanalysis of diverse DIA proteomics datasets using the latest DIA-NN versions, significantly improving protein identification rates and enabling large-scale meta-analyses through reproducible, cloud-ready processing.
This paper proposes the Multi-Counter Architecture of Replicative Aging (MCARA) hypothesis, which posits that the centriole acts as a non-repairable, stress-accumulating "hardware" clock distinct from the reprogrammable epigenetic "software," and predicts that eliminating centrioles prior to reprogramming will significantly enhance iPSC generation efficiency by resetting this aging registry.
This study utilizes a reproducible transcriptomic pipeline to reveal that colorectal cancer cell lines exhibit tissue-specific, divergent splicing modalities in the lncRNAs GAS5 and SNHG1—distinct from patterns observed in esophageal cancer—that are likely underreported in public databases due to tumor dilution and Poly-A selection biases.
This study successfully demonstrated the preparation of competent *E. coli* DH5α cells, their transformation with the pET M11 vector containing the human CXCL-10 gene, and the subsequent isolation of plasmid DNA from positive colonies to establish a foundation for future protein expression.
This study demonstrates that optimizing prediction thresholds for entropy-based LSTM and BiLSTM models significantly improves the precision of seven-day-ahead agitation forecasts in passive dementia monitoring, thereby reducing false alert burdens and establishing clinically actionable operating policies for rare-event detection.
This paper introduces the Conceptual Stress Propagation Model (CSPM), a qualitative framework proposing that individual stress in group-housed animals aggregates into emergent network dynamics through social transmission pathways, supported by exploratory stakeholder perceptions and accompanied by specific, falsifiable predictions for future empirical validation.