4404 papers
This study demonstrates that while taxonomic composition alone has limited value, integrating age with microbial ecological organization and inferred functional pathways significantly improves the prediction of clinical trajectories in women with low-grade cervical lesions.
This study demonstrates that dexmedetomidine alleviates sepsis-associated cognitive impairment in mice by activating the VLPO→mPFC pathway to restore NREM sleep and prefrontal synaptic plasticity.
This exploratory study utilized small RNA sequencing and RT-qPCR to identify specific placental miRNA candidates, such as hsa-miR-155-5p, hsa-miR-193a-5p, and hsa-miR-187-3p, that may serve as biomarkers or regulatory factors in the congenital transmission of *Trypanosoma cruzi*, though further functional validation is required.
Although the study confirms that song sparrows have undergone temporal acoustic changes over nearly three decades, the species' high population song variability prevents males from distinguishing between current and historical songs, resulting in no difference in their aggressive responses during playback experiments.
This study presents an integrative computational framework demonstrating that Alzheimer's disease-related microglial morphological simplification and cognitive impairments in 5xFAD mice exhibit pronounced sex-specific differences, with females showing more severe microglial alterations and males displaying broader behavioral deficits.
This study presents a high-quality de novo genome assembly of the Ethiopian staple enset (Ensete ventricosum) landrace Mazia and reveals that approximately 25% of its genome is unique compared to banana progenitors, providing critical genomic resources to accelerate targeted breeding for food security and drought tolerance.
This preliminary study indicates that while Nicotinamide mononucleotide (NMN) at concentrations of 50 and 100 µM does not impair human sperm progressive motility, a higher concentration of 150 µM significantly reduces motility, suggesting a dose-dependent reprotoxic effect that warrants further investigation.
This study demonstrates that Anoctamin 1 (ANO1) promotes malignant progression and epithelial–mesenchymal transition in head and neck squamous cell carcinoma by activating the ERK/YAP signaling pathway, thereby identifying it as a significant prognostic biomarker and potential therapeutic target.
This paper proposes a minimal synthetic cell model that quantifies metabolic aging as sugar-driven information loss by linking chiral scaffold degradation via non-enzymatic glycation to a measurable decrease in configurational entropy, thereby establishing a falsifiable, experimentally accessible framework where the balance between repair and glycation rates governs the system's resistance to metabolic drift.
This study demonstrates that the receptor kinase SCHENGEN3 uncouples root Casparian strip formation from systemic nutrient signaling by linking distinct receptor-ligand perception states to specific developmental and physiological outputs, revealing evolutionary divergence in pathway deployment between *Arabidopsis* and *Lotus*.