Nanoscale Tire Wear Particles Disrupt the Blood–Testis Barrier and Impair Spermatogenesis through Oxidative Stress–Driven Ferritinophagy and Ferroptosis
This study demonstrates that nanoscale tire wear particles impair spermatogenesis and disrupt the blood–testis barrier in mice by inducing oxidative stress, which triggers NCOA4-dependent ferritinophagy and subsequent ferroptosis.