4404 papers
The paper introduces LognormISI, a data-driven mixture-modeling method that overcomes the limitations of fixed-threshold detectors by identifying statistically separable burst phenotypes in basal ganglia spike trains with high specificity, offering a reproducible framework for analyzing burst-symptom associations in Parkinson's disease.
This study reveals that the association between retinal age gap and systemic diseases is inconsistent across age subgroups due to regression-to-the-mean effects and that model generalisability should be evaluated based on application-specific utility rather than age estimation accuracy alone.
This study utilizes single-nucleus RNA sequencing of postmortem human brain tissue to reveal that while Alzheimer's Disease and primary tauopathies share a conserved cerebrovascular heat-shock stress response, Alzheimer's Disease uniquely exhibits significant vascular remodeling and endothelial dysregulation at AD risk loci, highlighting the vasculature as a potential therapeutic target.
This study demonstrates that reduced LACTB expression in myeloid cells lowers Alzheimer's disease risk by increasing succinylcarnitine levels and enhancing oxidative phosphorylation, positioning LACTB as a promising inflammation-responsive therapeutic target for the disease.
This study of 728 European bats across five Bulgarian hibernacula reveals that while hibernation leads to significant species-, sex-, and roost-dependent declines in body mass and wing integrity alongside reduced ectoparasite loads, it does not cause oxidative deterioration in *Myotis blythii*, as evidenced by decreased DNA damage and altered antioxidant status.
This study reveals that exercise-induced muscle-derived FGF9 drives the hyperplastic expansion of subcutaneous white adipose tissue by activating a specific MGP-positive progenitor cell subset via the FGFR1/MAPK pathway, thereby improving insulin sensitivity and offering a potential therapeutic strategy for diabetes even in the absence of weight loss.
This study synthesizes morphological, molecular, and biochemical analyses of eleven Moroccan *Pistacia lentiscus* populations to reveal high, largely independent diversity across all levels driven by biological traits rather than geography, thereby advocating for the conservation of a broad network of stands, particularly in arid regions.
This study redefines trained immunity by identifying four functionally and epigenetically distinct programs (antibacterial, antiparasitic/pro-allergic, antiviral, and pro-repair) that establish a polarized framework of innate immune memory, demonstrated through specific molecular mechanisms and their differential engagement in human diseases.
This longitudinal multi-omics study of 294 mother-infant dyads in rural Burkina Faso reveals that growth faltering in small vulnerable newborns is driven by prenatal maternal vulnerabilities and postnatal disruptions in milk composition and infant gut ecology, with specific milk amino acids partially mediating persistent linear growth deficits.
This study reveals that pathogenic fungi in drinking water systems significantly enhance their chlorine resistance by actively binding metal ions from pipe corrosion, which triggers a multilayered defense mechanism involving physical barriers, chemical consumption, and intracellular metabolic remodeling that collectively impedes disinfection efficacy.