🧬 Category

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4404 papers

🧬 biology

Functional inertia reveals history-dependent organization of large-scale brain dynamics

This paper introduces "functional inertia" as a history-dependent, multilevel constraint on brain dynamics that structures activity into coherent regimes and explains how the same underlying mechanism can predict better cognitive performance in healthy individuals while driving greater symptom severity in schizophrenia, thereby reframing stability and volatility as context-dependent expressions of a single organizing principle.

Sir-Lord Wiafe, Vince Calhoun2026-07-13
🧬 biology

Genome-wide association analysis of growth traits in Tianzhu white yak

This study utilized low-coverage sequencing and genome-wide association analysis on 536 Tianzhu White Yak individuals to identify 366 significant SNP loci and 32 candidate genes associated with key growth traits, providing valuable genetic markers to advance precision breeding programs.

Guowu Yang, Xuedong Qi, Yongfu La, Xiaoming Ma, Yicheng Liu, Zhicheng Wang, Wenxue Luo, Wenwen Ren, Zhenyu Zhang, Min Ch (…)2026-07-13
🧬 biology

Effects of shoe longitudinal bending stiffness and runner level on Achilles tendon loading in experienced and novice male runners: a musculoskeletal modelling study

This musculoskeletal modelling study reveals that both runner experience level and increased shoe longitudinal bending stiffness independently elevate Achilles tendon loading, with novice runners adapting to stiffer shoes through proximal compensations while experienced runners do not, supporting an individualized approach to optimal shoe stiffness.

Shixin Lin, Hao Yuan, Jiaying Shao, Dongwei Liu, Mianfang Ruan, Ye Ma2026-07-13
🧬 biology

Identification of the type II NAD(P)H dehydrogenase gene family reveals that TaNDC1 positively regulate Fusarium head blight resistance in wheat

This study comprehensively characterizes the wheat type II NAD(P)H dehydrogenase (TaND) gene family and identifies TaNDC1 as a positive regulator of Fusarium head blight resistance that interacts with the Fhb1 locus protein TaPFT.

Puwen Song, Liuliu Wu, Ao Li, Dan Li, Yiyao Li, Ping Hu, Yuanyuan Guan, Meng Zhang, Qili Liu, Haiyan Hu, Zhengang Ru2026-07-13
🧬 biology

The rapid drop of metronidazole concentration in TYI-S-33 culture medium without Giardia trophozoites

This study reveals that metronidazole concentrations in TYI-S-33 culture medium rapidly decline due to chemical interactions with iron-cysteine clusters rather than solely due to Giardia trophozoite uptake, a phenomenon that significantly alters the interpretation of drug efficacy in experimental settings.

Rodrigo Chávez-Hernández, Martha Ponce-Macotela, Juan Carlos García-Ramos, Gustavo Esteban Peralta-Abarca, Yadira Rufino (…)2026-07-13✓ Author reviewed ⓘ
🧬 biology

In vitro assay and GC-MS profiling of Proteus sp.EKWG2I3 isolate obtained from Echinops kebericho Mesfin: A traditional medicinal plant

This study identifies the endophytic bacterium *Proteus* sp. EKWG2I3 from the medicinal plant *Echinops kebericho* as a promising source of bioactive compounds, demonstrating significant *in vitro* antibacterial and antioxidant activities alongside the identification of methyl phenylacetate and pentanoic acid methyl ester as its major constituents via GC-MS profiling.

Dinku Senbeta, Aman Dekebo, Seid Mohammed Ebu2026-07-13
🧬 biology

Clinical, cellular, and genomic consequences of a population-enriched SETD1A missense variant

This study characterizes a population-enriched SETD1A missense variant (P596L) that increases bipolar disorder risk and causes cognitive deficits by inducing SETD1A hypofunction, which disrupts chromatin regulation, triggers replication stress, and impairs neurodevelopmental timing in a manner that can be partially rescued by pharmacologic inhibition of H3K4 demethylase KDM5.

Seth Ament, Robert Lease, Rediet Oshone, Yumna Ahmed, Samaneh Ali, Sterling Arjona, Jayme Choe, Carlo Colantuoni, Marcia (…)2026-07-13
🧬 biology

Guarded LINCS/L1000 reversal of severe equine asthma recovers disease biology but no coherent non-steroidal reversal class

This study demonstrates that while severe equine asthma possesses a robust, cross-species-queryable transcriptomic signature, a guarded LINCS/L1000 computational reversal approach successfully filters out standard-of-care drugs but fails to identify a coherent class of non-steroidal therapeutic candidates, thereby validating the framework as a rigorous anti-circularity benchmark rather than a direct path to new drug nominations.

Cleverson de Souza2026-07-13