4404 papers
This study introduces "BrainYears," a scalable, non-invasive, and cost-effective EEG-based machine learning model that accurately predicts chronological age using 643 neural features captured by a Sens.ai headset, offering a repeatable functional biomarker for assessing brain aging outside clinical settings.
This study developed a cross-tissue WGCNA pipeline anchored in the entorhinal cortex to identify a conserved five-gene transcriptomic signature in peripheral blood that effectively distinguishes asymptomatic Alzheimer's disease patients from healthy controls.
This study demonstrates that c-Myc is significantly upregulated in idiopathic pulmonary fibrosis, where it acts as a critical pathogenic driver of myofibroblast activation and cellular senescence via the TGF-β1/Smad signaling pathway, suggesting that targeting c-Myc offers a promising therapeutic strategy for the disease.
This study investigates the transferability and output-level effects of semantic alignment in protein sequence design by applying an AGSDD-inspired approach to MapDiff, finding that while it improves perplexity and increases semantic attention, it primarily acts as a distributional regularizer without significantly enhancing biochemical similarity or median recovery.
This study demonstrates that host immune endotype dictates the outcome of combined antibiotic and colitis injury, where Th1-biased immunity drives IL-1β-dominated inflammation and metabolic dysregulation, while Th2-biased immunity promotes mucosal recovery through distinct anti-inflammatory metabolic circuits, highlighting the need for endotype-tailored therapies in IBD.
This study demonstrates that liposomal daunorubicin exhibits superior cytotoxicity against HCT116 colorectal cancer cells compared to free daunorubicin by significantly enhancing oxidative stress, suppressing ERK1/2 gene expression, and inducing apoptotic morphological changes.
This study introduces a resampling framework demonstrating that enterotype assignments in clinical microbiome studies are often unstable and cohort-dependent, identifying a subset of "variable" individuals whose classifications fluctuate based on cohort composition while "core" individuals remain stable, thereby offering practical tools to determine when reliable four-enterotype stratification is feasible versus when simplified grouping is necessary.
This study reveals that miR-513a drives breast cancer progression by directly targeting and suppressing SIRT3, which subsequently activates the Notch1 signaling pathway to induce glycolytic reprogramming, epithelial–mesenchymal transition, and increased invasiveness.
By integrating whole-genome sequencing and single-cell RNA sequencing, this study reveals that ALS pathology arises from a multi-hit genetic architecture that converges on a stress-induced, inflammatory immune transcriptome characterized by the activation of innate lymphocyte populations.
This prospective neuroimaging study of 1,804 participants defines resilience as better-than-expected depressive outcomes relative to cumulative risk and reveals that while no immediate structural brain differences were found, higher resilience predicts a subsequent reduction in gray matter volume in the left inferior orbitofrontal gyrus and temporal pole, potentially reflecting neural efficiency or delayed biological costs.