4404 papers
This study identifies distinct CD146⁺ endothelial and pericyte populations that drive a repair-associated neovascularization program in rheumatoid arthritis pannus through specific transcriptional signatures and active intercellular communication.
The study introduces Nanomito, an amplification-free long-read nanopore sequencing workflow that outperforms routine PCR-based methods by providing accurate, full-length analysis of mitochondrial DNA, enabling reliable quantification of heteroplasmy and precise detection of large-scale deletions without amplification bias.
This paper proposes a multidimensional dynamical systems framework that represents conscious states as vectors comprising physical, cognitive, and noetic components to establish a shared mathematical language for mapping neuroelectromagnetic field dynamics to subjective experience and empirically comparing competing consciousness theories.
By combining transcript-to-genome alignments with alignment-free k-mer screening, this study demonstrates that sequence-detectable homologs of human lncRNAs are far more widespread across great ape genomes than previously recognized, revealing a substantial persistence of lncRNA-associated sequences despite their rapid evolution.
This study demonstrates that beta2* nicotinic acetylcholine receptors in the mouse prefrontal cortex regulate social and exploratory behaviors through functionally distinct neuronal populations, where knockdown in superficial-layer 5HT3a-expressing interneurons induces a robust hypersocial phenotype, while knockdown in mixed deep-layer neurons or striatal NPY-expressing cells produces opposing or milder effects, highlighting the necessity of cell-type-specific targeting for therapeutic interventions.
This study establishes a novel 3D spatial proteomics workflow to map the human pancreatic islet microenvironment at 50 µm resolution, revealing four distinct molecular zones including a previously underappreciated peri-islet niche, and provides an interactive platform for visualizing these spatial protein profiles to advance disease research.
This study presents a cultivar-resolved assembly and comprehensive characterization of the *Medicago sativa* cv. AH mitochondrial genome, revealing repeat-mediated structural isoforms, plastid-to-mitochondrion DNA transfers, extensive RNA editing landscapes, and intraspecific synteny rearrangements to advance understanding of cytoplasmic diversity in alfalfa.
While soil origin provides the diverse bacterial pool for legume-associated microbiomes, host plant identity acts as the primary filter that selectively recruits and structures these communities, resulting in distinct, host-specific bacterial assemblages.
This study challenges the long-held assumption that spike train matching and waveform tracking are interchangeable methods for identifying motor units across recordings, demonstrating through analysis of over 14,000 units that their agreement is highly dependent on dataset-specific characteristics and threshold selection, thereby necessitating dataset-specific calibration rather than universal thresholds.
This study demonstrates that vascular biomarkers derived from brain, blood, and cerebrospinal fluid in Parkinson's disease reflect distinct biological processes rather than interchangeable signals, challenging the assumption that these measures can be used interchangeably for biomarker validation.