4404 papers
This study demonstrates that genome-based subtyping of early Parkinson's disease identifies three reproducible clusters with distinct motor progression rates and clinical outcomes, offering a strategy to enrich clinical trial cohorts and significantly reduce required sample sizes.
This study resolves conflicting findings on hand-action sequence effects by demonstrating that action magnitude drives an asymmetric pattern where precision actions inhibit subsequent power actions while power actions facilitate precision ones, a biomechanical hierarchy that overrides social cues and supports an integrated model of neural inhibitory mechanisms.
This study of unmanaged broadleaved forests in Sarpang, Bhutan, reveals that while distinct forest types exhibit detectable but weak compositional differences across elevational gradients, the limited predictive power of environmental variables and regeneration models underscores the necessity for finer-scale microclimate and soil data to fully understand Himalayan forest community dynamics.
This study integrates cytogenetic, biochemical, and RAPD molecular analyses to demonstrate significant genetic diversity among ten wild *Capparis spinosa* accessions from Central Saudi Arabia, providing essential baseline data for the species' conservation and sustainable utilization.
This study reveals that KRAS upregulates TMEM87A to stabilize the cholesterol-biosynthetic enzyme EBP, thereby promoting the accumulation of anti-ferroptotic sterols (7-DHC and 7-DHD) and driving pancreatic cancer progression, which suggests that targeting this axis offers a promising therapeutic strategy for KRAS-mutant pancreatic ductal adenocarcinoma.
This study demonstrates that *Zymomonas mobilis* strain ZM6 produces bioactive metabolites, including diketopiperazines and D-allose-rich fractions, which exhibit potent antibacterial activity against multidrug-resistant pathogens and enhance glucose uptake in insulin-resistant cells, despite the absence of canonical biosynthetic gene clusters in its genome.
This paper demonstrates that a dual-pipeline framework utilizing quantum kernel support vector machines, combined with rigorous post-hoc calibration and interpretability techniques, significantly outperforms classical baselines in distinguishing psychiatric disorders using neuroimaging data while achieving high predictive accuracy and biological credibility.
This study utilizes an integrated network pharmacology and computational framework to identify carvacrol and pulegone from *Anacardium occidentale* as promising multi-target therapeutic candidates for pancreatic ductal adenocarcinoma, with carvacrol demonstrating superior thermodynamic stability and binding affinity against the MMP9 protein.
This paper proposes the Host Energetic Allocation Model (HEAM), a deterministic biophysical framework demonstrating that epigenetic hysteresis traps myeloid cells in a high-metabolic state after viral clearance, thereby causing chronic neural energy depletion and explaining the pathophysiology of post-acute infection syndromes like Long COVID.
This study demonstrates that human umbilical cord mesenchymal stem cells (hUC-MSCs) effectively treat photoaged mouse skin and associated systemic organ damage by restoring mitochondrial autophagy, with combined local and tail-vein injection proving to be the most effective therapeutic strategy.